Transcriptional and functional insights into the host immune response against the emerging fungal pathogen Candida auris.
Journal
Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
10
07
2019
accepted:
27
07
2020
pubmed:
26
8
2020
medline:
27
2
2021
entrez:
26
8
2020
Statut:
ppublish
Résumé
Candida auris is among the most important emerging fungal pathogens, yet mechanistic insights into its immune recognition and control are lacking. Here, we integrate transcriptional and functional immune-cell profiling to uncover innate defence mechanisms against C. auris. C. auris induces a specific transcriptome in human mononuclear cells, a stronger cytokine response compared with Candida albicans, but a lower macrophage lysis capacity. C. auris-induced innate immune activation is mediated through the recognition of C-type lectin receptors, mainly elicited by structurally unique C. auris mannoproteins. In in vivo experimental models of disseminated candidiasis, C. auris was less virulent than C. albicans. Collectively, these results demonstrate that C. auris is a strong inducer of innate host defence, and identify possible targets for adjuvant immunotherapy.
Identifiants
pubmed: 32839538
doi: 10.1038/s41564-020-0780-3
pii: 10.1038/s41564-020-0780-3
pmc: PMC9204844
mid: NIHMS1810177
doi:
Substances chimiques
Cytokines
0
Lectins, C-Type
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1516-1531Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM083016
Pays : United States
Organisme : Medical Research Council
ID : MR/M026663/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M026663/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N006364/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N006364/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NCRR NIH HHS
ID : C06 RR030651
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM119197
Pays : United States
Commentaires et corrections
Type : CommentIn
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