Small Cell Variant of Medullary Thyroid Carcinoma: A Possible Treatment.
calcitonin
hypothyroidism
levothyroxine
medullary thyroid carcinoma
multiple endocrine neoplasia
nausea
octreotide
small cell variant
thyroid-stimulating hormone
vomiting
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
20 Jul 2020
20 Jul 2020
Historique:
entrez:
26
8
2020
pubmed:
26
8
2020
medline:
26
8
2020
Statut:
epublish
Résumé
Small cell variant of medullary thyroid carcinoma is an extremely rare histologic entity with a paucity of data. As such, there is a lack of literature and clinical experience regarding this disease. In this report, we examine a case of small cell variant of medullary thyroid carcinoma that presented with intractable nausea, vomiting and diarrhea. While these symptoms were essentially refractory to the standard symptomatic treatment, further laboratory analysis revealed dramatically elevated calcitonin levels and mildly raised thyroid-stimulating hormone levels. Interestingly, repletion of thyroid hormone and treatment with lanreotide resulted in an abatement of our patient's symptoms. This temporal clinical improvement highly suggests a potential role involving thyroid-stimulating hormone and calcitonin levels in the pathogenesis of this disease, and consequently suggests a role for thyroxine in treating the associated gastrointestinal symptoms.
Identifiants
pubmed: 32839675
doi: 10.7759/cureus.9305
pmc: PMC7440271
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e9305Informations de copyright
Copyright © 2020, Sherret et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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