Oncolytic Virus with Attributes of Vesicular Stomatitis Virus and Measles Virus in Hepatobiliary and Pancreatic Cancers.
cholangiocarcinoma
hepatobiliary cancer
hepatocellular carcinoma
measles virus
oncolytic viral therapy
pancreatic cancer
vesicular stomatitis virus
Journal
Molecular therapy oncolytics
ISSN: 2372-7705
Titre abrégé: Mol Ther Oncolytics
Pays: United States
ID NLM: 101666776
Informations de publication
Date de publication:
25 Sep 2020
25 Sep 2020
Historique:
received:
17
02
2020
accepted:
14
08
2020
pubmed:
26
8
2020
medline:
26
8
2020
entrez:
26
8
2020
Statut:
ppublish
Résumé
Recombinant vesicular stomatitis virus (VSV)-fusion and hemagglutinin (FH) was developed by substituting the promiscuous VSV-G glycoprotein (G) gene in the backbone of VSV with genes encoding for the measles virus envelope proteins F and H. Hybrid VSV-FH exhibited a multifaceted mechanism of cancer-cell killing and improved neurotolerability over parental VSV in preclinical studies. In this study, we evaluated VSV-FH
Identifiants
pubmed: 32839735
doi: 10.1016/j.omto.2020.08.007
pii: S2372-7705(20)30124-8
pmc: PMC7437509
doi:
Types de publication
Journal Article
Langues
eng
Pagination
546-555Subventions
Organisme : NCI NIH HHS
ID : R01 CA175795
Pays : United States
Organisme : NCI NIH HHS
ID : K01 CA234324
Pays : United States
Organisme : NCI NIH HHS
ID : DP2 CA195764
Pays : United States
Organisme : FDA HHS
ID : R01 FD004781
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA210964
Pays : United States
Informations de copyright
© 2020 The Author(s).
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