Socio-demographic heterogeneity in the prevalence of COVID-19 during lockdown is associated with ethnicity and household size: Results from an observational cohort study.
BAME
COVID-19
Ethnicity
Lockdown
SARS-CoV-2
Journal
EClinicalMedicine
ISSN: 2589-5370
Titre abrégé: EClinicalMedicine
Pays: England
ID NLM: 101733727
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
pubmed:
26
8
2020
medline:
26
8
2020
entrez:
26
8
2020
Statut:
ppublish
Résumé
Accumulating evidence indicates that COVID-19 causes adverse outcomes in ethnic minority groups. However, little is known about the impact of ethnicity and household size on acquiring infection with SARS-CoV-2. We undertook a retrospective cohort study, in Leicester (UK), of all individuals assessed for COVID-19 with polymerase chain reaction (PCR) testing at University Hospitals of Leicester NHS Trust between 1st March and 28th April 2020. We used logistic regression to identify sociodemographic, clinical and temporal factors associated with SARS-CoV-2 PCR positivity before/after lockdown. 971/4051 (24.0%) patients with suspected COVID-19 were found to be PCR positive for SARS-CoV-2. PCR positivity was more common amongst individuals from ethnic minortiy backgrounds than their White counterparts (White 20.0%, South Asian 37.5%, Black 36.1%, Other 32.2%; In individuals presenting with suspected COVID-19, those from ethnic minority communities and larger households had an increased likelihood of SARS-CoV-2 PCR positivity. Pandemic control measures may have more rapid impact on slowing viral transmission amongst those of White ethnicity compared to ethnic minority groups, Research is urgently required to understand the mechanisms underlying these disparities and whether public health interventions have differential effects on individuals from ethnic minority groups. 10.13039/100006662 NIHR.
Sections du résumé
BACKGROUND
BACKGROUND
Accumulating evidence indicates that COVID-19 causes adverse outcomes in ethnic minority groups. However, little is known about the impact of ethnicity and household size on acquiring infection with SARS-CoV-2.
METHODS
METHODS
We undertook a retrospective cohort study, in Leicester (UK), of all individuals assessed for COVID-19 with polymerase chain reaction (PCR) testing at University Hospitals of Leicester NHS Trust between 1st March and 28th April 2020. We used logistic regression to identify sociodemographic, clinical and temporal factors associated with SARS-CoV-2 PCR positivity before/after lockdown.
FINDINGS
RESULTS
971/4051 (24.0%) patients with suspected COVID-19 were found to be PCR positive for SARS-CoV-2. PCR positivity was more common amongst individuals from ethnic minortiy backgrounds than their White counterparts (White 20.0%, South Asian 37.5%, Black 36.1%, Other 32.2%;
INTERPRETATION
CONCLUSIONS
In individuals presenting with suspected COVID-19, those from ethnic minority communities and larger households had an increased likelihood of SARS-CoV-2 PCR positivity. Pandemic control measures may have more rapid impact on slowing viral transmission amongst those of White ethnicity compared to ethnic minority groups, Research is urgently required to understand the mechanisms underlying these disparities and whether public health interventions have differential effects on individuals from ethnic minority groups.
FUNDING
BACKGROUND
10.13039/100006662 NIHR.
Identifiants
pubmed: 32840492
doi: 10.1016/j.eclinm.2020.100466
pii: S2589-5370(20)30210-8
pii: 100466
pmc: PMC7366113
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100466Subventions
Organisme : Medical Research Council
ID : MR/V027549/1
Pays : United Kingdom
Organisme : Department of Health
ID : PDF-2015-08-102
Pays : United Kingdom
Informations de copyright
© 2020 The Author(s).
Déclaration de conflit d'intérêts
Dr. Minhas reports grants from National Institute for Health Research (NIHR), during the conduct of the study; Dr. Tang reports personal fees from Abbvie UK Ltd, outside the submitted work; Professor Davies reports grants from NIHR BRC, during the conduct of the study; Dr. Pareek reports grants and personal fees from Gilead Sciences and personal fees from QIAGEN, outside the submitted work.
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