Signaling pathways and microRNAs, the orchestrators of NANOG activity during cancer induction.
Cancer
Cancer stem cells
NANOG
Signaling pathways
microRNAs
Journal
Life sciences
ISSN: 1879-0631
Titre abrégé: Life Sci
Pays: Netherlands
ID NLM: 0375521
Informations de publication
Date de publication:
01 Nov 2020
01 Nov 2020
Historique:
received:
08
07
2020
revised:
18
08
2020
accepted:
20
08
2020
pubmed:
26
8
2020
medline:
11
11
2020
entrez:
26
8
2020
Statut:
ppublish
Résumé
Cancer stem cells (CSCs) are a small part of cancer cells inside the tumor that have similar characteristics to normal stem cells. CSCs stimulate tumor initiation and progression in a variety of cancers. Several transcription factors such as NANOG, SOX2, and OCT4 maintain the characteristics of CSCs and their upregulation is seen in many malignancies resulting in increased metastasis, invasion, and recurrence. Among these factors, NANOG plays an important role in regulating the self-renewal and pluripotency of CSCs and the clinical significance of NANOG has been suggested as a marker of CSCs in many cancers. The up and down-regulation of NANOG is associated with several important signaling pathways, including JAK/STAT, Wnt/β-catenin, Notch, TGF-β, Hedgehog, and several microRNAs (miRNAs). In this review, we will investigate the function of NANOG in CSCs and the molecular mechanism of its regulation by signaling pathways and miRNAs. We will also investigate targeting NANOG with different techniques, which is a promising treatment strategy for cancer treatment.
Identifiants
pubmed: 32841661
pii: S0024-3205(20)31089-4
doi: 10.1016/j.lfs.2020.118337
pii:
doi:
Substances chimiques
MicroRNAs
0
NANOG protein, human
0
Nanog Homeobox Protein
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
118337Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.