Circulating MicroRNAs as Prognostic and Therapeutic Biomarkers in Breast Cancer Molecular Subtypes.
biomarkers
breast cancer
circulating microRNA
microRNA
molecular subtypes
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
22 Aug 2020
22 Aug 2020
Historique:
received:
06
08
2020
revised:
17
08
2020
accepted:
20
08
2020
entrez:
27
8
2020
pubmed:
28
8
2020
medline:
28
8
2020
Statut:
epublish
Résumé
Breast cancer (BC) is a common and heterogeneous disease, of which six molecular subtypes, characterized by different biological features and clinical outcomes, were described. The identification of additional biomarkers able to further connote and distinguish the different BC subtypes is essential to improve the diagnostic, prognostic and therapeutic strategies in BC patients. MicroRNAs (miRNAs) are short non-coding RNA involved in several physiological and pathological processes, including cancer development and progression. In particular, circulating miRNAs, which can be found in an adequately stable structure in serum/plasma of cancer patients, are emerging as very promising non-invasive biomarkers. Several studies have analyzed the potential role of circulating miRNAs as prognostic and therapeutic markers in BC. In the present review we describe circulating miRNAs, identified as putative biomarker in BC, with special reference to different BC molecular subtypes.
Identifiants
pubmed: 32842653
pii: jpm10030098
doi: 10.3390/jpm10030098
pmc: PMC7563822
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : MIUR-FIRB grant
ID : RBAP10A9H9 to Edoardo Alesse
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