Is opium use associated with an increased risk of lung cancer? A case-control study.
Age Factors
Aged
Alcohol Drinking
/ adverse effects
Case-Control Studies
Cigarette Smoking
/ adverse effects
Female
Healthy Volunteers
Humans
Iran
/ epidemiology
Lung Neoplasms
/ epidemiology
Male
Middle Aged
Non-Smokers
/ statistics & numerical data
Opium
/ adverse effects
Registries
/ statistics & numerical data
Risk Factors
Smokers
/ statistics & numerical data
Smoking, Non-Tobacco Products
/ adverse effects
Case-control
Lung neoplasm
Opioids
Risk factor
Journal
BMC cancer
ISSN: 1471-2407
Titre abrégé: BMC Cancer
Pays: England
ID NLM: 100967800
Informations de publication
Date de publication:
26 Aug 2020
26 Aug 2020
Historique:
received:
21
09
2019
accepted:
12
08
2020
entrez:
27
8
2020
pubmed:
28
8
2020
medline:
7
4
2021
Statut:
epublish
Résumé
In recent years, lung cancer (LC) incidence has increased in Iran. The use of opium and its derivatives (O&D) has increased as well. This study aimed to investigate the association between the use of O&D and LC incidence. In this case-control study conducted in Kerman, Iran; 140 patients with lung cancer and 280 healthy controls matched by age, sex, and place of residence were included. Data, including O&D use, cigarette smoking, alcohol use, and diet, were collected using a structured questionnaire. The relation between the use of O&D and LC was evaluated using conditional logistic regression adjusted for tobacco smoking, education, daily intake of fruit, vegetables, red meat, and hydrogenated fats. Opium ever-use was associated with an increased risk of LC (Adjusted Odds Ratio (AOR) =5.95, 95% CI: 1.87-18.92). Participants were divided into low and high use groups based on the median of opium use in the control group. A significant dose-response relation was observed between the amount of daily O&D use and LC; and the relation was stronger in high users (AOR The results of this study show that opium use is probably a dose related risk factor for lung cancer.
Sections du résumé
BACKGROUND
BACKGROUND
In recent years, lung cancer (LC) incidence has increased in Iran. The use of opium and its derivatives (O&D) has increased as well. This study aimed to investigate the association between the use of O&D and LC incidence.
METHODS
METHODS
In this case-control study conducted in Kerman, Iran; 140 patients with lung cancer and 280 healthy controls matched by age, sex, and place of residence were included. Data, including O&D use, cigarette smoking, alcohol use, and diet, were collected using a structured questionnaire. The relation between the use of O&D and LC was evaluated using conditional logistic regression adjusted for tobacco smoking, education, daily intake of fruit, vegetables, red meat, and hydrogenated fats.
RESULTS
RESULTS
Opium ever-use was associated with an increased risk of LC (Adjusted Odds Ratio (AOR) =5.95, 95% CI: 1.87-18.92). Participants were divided into low and high use groups based on the median of opium use in the control group. A significant dose-response relation was observed between the amount of daily O&D use and LC; and the relation was stronger in high users (AOR
CONCLUSION
CONCLUSIONS
The results of this study show that opium use is probably a dose related risk factor for lung cancer.
Identifiants
pubmed: 32842991
doi: 10.1186/s12885-020-07296-0
pii: 10.1186/s12885-020-07296-0
pmc: PMC7448970
doi:
Substances chimiques
Opium
8008-60-4
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
807Subventions
Organisme : Kerman University of Medical Sciences
ID : 95000555
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