Impairment of spatial memory accuracy improved by Cbr1 copy number resumption and GABA
Alcohol Oxidoreductases
/ genetics
Animals
Brain
/ metabolism
DNA Copy Number Variations
Disease Models, Animal
Down Syndrome
/ genetics
Female
Hippocampus
/ metabolism
Inhibition, Psychological
Male
Mice
Mice, Inbred C57BL
Receptors, GABA-B
/ genetics
Spatial Memory
/ physiology
Synapses
/ genetics
gamma-Aminobutyric Acid
/ genetics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
25 08 2020
25 08 2020
Historique:
received:
21
04
2020
accepted:
10
08
2020
entrez:
27
8
2020
pubmed:
28
8
2020
medline:
12
1
2021
Statut:
epublish
Résumé
Down syndrome is a complex genetic disorder caused by the presence of three copies of the chromosome 21 in humans. The most common models, carrying extra-copies of overlapping fragments of mouse chromosome 16 that is syntenic to human chromosome 21, are Ts2Cje, Ts1Cje and Ts1Rhr mice. In electrophysiological analyses using hippocampal slices, we found that the later phase of the depolarization during tetanic stimulation, which was regulated by GABA
Identifiants
pubmed: 32843708
doi: 10.1038/s41598-020-71085-9
pii: 10.1038/s41598-020-71085-9
pmc: PMC7447763
doi:
Substances chimiques
Receptors, GABA-B
0
gamma-Aminobutyric Acid
56-12-2
Alcohol Oxidoreductases
EC 1.1.-
carbonyl reductase 1, mouse
EC 1.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14187Références
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