Fibrinogen and LDL Influence on Blood Viscosity and Outcome of Acute Ischemic Stroke Patients in Indonesia.
Acute ischemic stroke
LDL
blood viscosity
fibrinogen
Journal
Annals of neurosciences
ISSN: 0972-7531
Titre abrégé: Ann Neurosci
Pays: United States
ID NLM: 101523367
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
entrez:
27
8
2020
pubmed:
28
8
2020
medline:
28
8
2020
Statut:
ppublish
Résumé
To assess the role of risk factors of metabolic syndrome on blood viscosity and the prognosis of acute ischemic stroke in Indonesia based on the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS). This study included 135 patients with acute ischemic stroke. Patients underwent measurements of viscosity and risk factor assessment. Analysis was performed to assess the role of these risk factors for blood viscosity and outcomes of acute ischemic stroke with NIHSS and mRS as indicators. NIHSS was assessed at <3 days after onset and 7 days after onset, while mRS was assessed 1 month post treatment. Bivariate analysis was performed using chi-square test, and variables with Factors affecting blood viscosity are fibrinogen, low-density lipoprotein (LDL), and hematocrit. Factors affecting NIHSS and mRS are fibrinogen and LDL. Fibrinogen and LDL affect the viscosity of blood and outcomes in acute ischemic stroke patients, so it is necessary to treat in the primary and secondary prevention of ischemic stroke.
Sections du résumé
BACKGROUND
BACKGROUND
To assess the role of risk factors of metabolic syndrome on blood viscosity and the prognosis of acute ischemic stroke in Indonesia based on the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS).
METHODS
METHODS
This study included 135 patients with acute ischemic stroke. Patients underwent measurements of viscosity and risk factor assessment. Analysis was performed to assess the role of these risk factors for blood viscosity and outcomes of acute ischemic stroke with NIHSS and mRS as indicators. NIHSS was assessed at <3 days after onset and 7 days after onset, while mRS was assessed 1 month post treatment. Bivariate analysis was performed using chi-square test, and variables with
RESULTS
RESULTS
Factors affecting blood viscosity are fibrinogen, low-density lipoprotein (LDL), and hematocrit. Factors affecting NIHSS and mRS are fibrinogen and LDL.
CONCLUSION
CONCLUSIONS
Fibrinogen and LDL affect the viscosity of blood and outcomes in acute ischemic stroke patients, so it is necessary to treat in the primary and secondary prevention of ischemic stroke.
Identifiants
pubmed: 32843830
doi: 10.1177/0972753119900630
pii: 10.1177_0972753119900630
pmc: PMC7418568
doi:
Types de publication
Journal Article
Langues
eng
Pagination
30-34Informations de copyright
© 2020 Indian Academy of Neurosciences (IAN).
Références
Neurotherapeutics. 2011 Jul;8(3):319-29
pubmed: 21691873
Clin Hemorheol Microcirc. 2004;31(1):1-9
pubmed: 15272148
Clin Hemorheol Microcirc. 2014;57(3):267-74
pubmed: 23445635
Korean Circ J. 2011 Jun;41(6):287-95
pubmed: 21779279
Am J Clin Pathol. 2006 Jun;125 Suppl:S78-86
pubmed: 16830959
Acta Med Indones. 2014 Jul;46(3):226-32
pubmed: 25348185
Eur Neurol. 1983;22 Suppl 1:35-7
pubmed: 6884403
Clin Hemorheol Microcirc. 2006;35(1-2):207-12
pubmed: 16899929
PLoS One. 2011 Mar 28;6(3):e18167
pubmed: 21464904
Neurology. 2008 Apr 8;70(15):1238-43
pubmed: 18322264
Thromb Res. 1976 May;8(2 suppl):25-33
pubmed: 936079