Responsible Translational Pathways for Germline Gene Editing?
Clinical utility
Ethics
Gene editing
Germline
Human subjects research
Reproductive medicine
Journal
Current stem cell reports
ISSN: 2198-7866
Titre abrégé: Curr Stem Cell Rep
Pays: Switzerland
ID NLM: 101650643
Informations de publication
Date de publication:
2020
2020
Historique:
pubmed:
28
8
2020
medline:
28
8
2020
entrez:
27
8
2020
Statut:
ppublish
Résumé
Continued development of gene editing techniques has raised the real possibility of clinical application of germline gene editing. These results, as well as reports of an unethical experiment which resulted in the birth of at least two children from edited embryos in 2018, have highlighted the urgency and importance of ethical issues about translational pathways for editing of human germline cells. Charting responsible translational pathways for germline gene editing requires tackling some significant and complex ethical issues. A literature on development of clinical applications of germline gene editing is emerging, and several key ethical issues are coming into focus as major challenges for responsible translational pathways. Potential clinical utility, clinical justification, and human subjects research for germline gene editing raise outstanding ethical questions. Work on these questions will help provide guidance to researchers and clinicians and direct translational projects toward justifiable applications.
Identifiants
pubmed: 32844082
doi: 10.1007/s40778-020-00179-x
pii: 179
pmc: PMC7441015
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
126-133Informations de copyright
© Springer Nature Switzerland AG 2020.
Déclaration de conflit d'intérêts
Conflict of InterestDr. Cwik reports grants from the National Human Genome Research Institute during the conduct of the study; and the author is a member of the external advisory board for the Oregon Health and Science University Center for Embryonic Cell and Gene Therapy. Members of this center were involved in public research discussed in this paper.
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