Lipoproteins and the Tumor Microenvironment.

Humans Lipoproteins / metabolism Neoplasms / metabolism Tumor Microenvironment
Adipose cells Endothelial cells Exosomes Fibroblasts High-density lipoproteins Immune surveillance Lipoproteins Macrophage polarization Macrophages Metastasis Microvasculature Neutrophils Pericytes Tumor aggressiveness Tumor environment

Journal

Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103

Informations de publication

Date de publication:
2020
Historique:
entrez: 27 8 2020
pubmed: 28 8 2020
medline: 21 10 2020
Statut: ppublish

Résumé

The tumor microenvironment (TME) plays a key role in enhancing the growth of malignant tumors and thus contributing to "aggressive phenotypes," supporting sustained tumor growth and metastasis. The precise interplay between the numerous components of the TME that contribute to the emergence of these aggressive phenotypes is yet to be elucidated and currently under intense investigation. The purpose of this article is to identify specific role(s) for lipoproteins as part of these processes that facilitate (or oppose) malignant growth as they interact with specific components of the TME during tumor development and treatment. Because of the scarcity of literature reports regarding the interaction of lipoproteins with the components of the tumor microenvironment, we were compelled to explore topics that were only tangentially related to this topic, to ensure that we have not missed any important concepts.

Identifiants

DOI: 10.1007/978-3-030-48457-6_6 PMID: 32845504
pubmed: 32845504
doi: 10.1007/978-3-030-48457-6_6
doi:

Substances chimiques

Lipoproteins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

93-116

Auteurs

Akpedje Serena Dossou (AS)

Lipoprotein Drug Delivery Research Laboratory, Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA.

Nirupama Sabnis (N)

Lipoprotein Drug Delivery Research Laboratory, Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA.

Bhavani Nagarajan (B)

Lipoprotein Drug Delivery Research Laboratory, Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA.

Ezek Mathew (E)

Lipoprotein Drug Delivery Research Laboratory, Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA.

Rafal Fudala (R)

Lipoprotein Drug Delivery Research Laboratory, Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA.
Department of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, TX, USA.

Andras G Lacko (AG)

Lipoprotein Drug Delivery Research Laboratory, Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA. Andras.lacko@unthsc.edu.
Departments of Physiology/Anatomy and Pediatrics, University of North Texas Health Science Center, Fort Worth, TX, USA. Andras.lacko@unthsc.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Lipoproteins and the Tumor Microenvironment.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Lipoproteins and the Tumor Microenvironment.
questionsmedicales.fr › Tumeurs › Lipoproteins and the Tumor Microenvironment.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Lipoproteins and the Tumor Microenvironment.