Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity.

Animals Autophagy / genetics GTP Phosphohydrolases / metabolism Mice Mitochondria / metabolism Phagocytosis / genetics Reactive Oxygen Species
apoptotic bodies inflammation lipopolysaccharide (LPS) macrophages mitochondria mitofusin phagocytosis protein degradation reactive oxygen species (ROS) septic shock

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
25 08 2020
Historique:
received: 27 07 2018
revised: 02 07 2020
accepted: 05 08 2020
entrez: 27 8 2020
pubmed: 28 8 2020
medline: 3 6 2021
Statut: ppublish

Résumé

Mitofusin 2 (Mfn2) plays a major role in mitochondrial fusion and in the maintenance of mitochondria-endoplasmic reticulum contact sites. Given that macrophages play a major role in inflammation, we studied the contribution of Mfn2 to the activity of these cells. Pro-inflammatory stimuli such as lipopolysaccharide (LPS) induced Mfn2 expression. The use of the Mfn2 and Mfn1 myeloid-conditional knockout (KO) mouse models reveals that Mfn2 but not Mfn1 is required for the adaptation of mitochondrial respiration to stress conditions and for the production of reactive oxygen species (ROS) upon pro-inflammatory activation. Mfn2 deficiency specifically impairs the production of pro-inflammatory cytokines and nitric oxide. In addition, the lack of Mfn2 but not Mfn1 is associated with dysfunctional autophagy, apoptosis, phagocytosis, and antigen processing. Mfn2

Identifiants

DOI: 10.1016/j.celrep.2020.108079 PMID: 32846136
pubmed: 32846136
pii: S2211-1247(20)31064-0
doi: 10.1016/j.celrep.2020.108079
pii:
doi:

Substances chimiques

Reactive Oxygen Species 0
GTP Phosphohydrolases EC 3.6.1.-
Mfn2 protein, mouse EC 3.6.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108079

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

Auteurs

Juan Tur (J)

Macrophage Biology Group, Department of Cell Biology, Physiology and Immunology, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain.

Selma Pereira-Lopes (S)

Macrophage Biology Group, Department of Cell Biology, Physiology and Immunology, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain.

Tania Vico (T)

Macrophage Biology Group, Department of Cell Biology, Physiology and Immunology, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain.

Eros A Marín (EA)

Macrophage Biology Group, Department of Cell Biology, Physiology and Immunology, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain.

Juan P Muñoz (JP)

Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 08036 Barcelona, Spain; Institute for Research in Biomedicine (IRB Barcelona), 08028 Barcelona, Spain; Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain.

Maribel Hernández-Alvarez (M)

Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 08036 Barcelona, Spain; Institute for Research in Biomedicine (IRB Barcelona), 08028 Barcelona, Spain; Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain.

Pere-Joan Cardona (PJ)

Unitat de tuberculosi experimental, Institut Germans Trias i Pujol, Badalona, Spain.

Antonio Zorzano (A)

Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 08036 Barcelona, Spain; Institute for Research in Biomedicine (IRB Barcelona), 08028 Barcelona, Spain; Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain.

Jorge Lloberas (J)

Macrophage Biology Group, Department of Cell Biology, Physiology and Immunology, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain. Electronic address: jlloberas@ub.edu.

Antonio Celada (A)

Macrophage Biology Group, Department of Cell Biology, Physiology and Immunology, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain. Electronic address: acelada@ub.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mitofusin 2 in Macrophages Links Mitochondrial...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › Mitofusin 2 in Macrophages Links Mitochondrial...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Acid anhydride hydrolases › dGTPases › Mitofusin 2 in Macrophages Links Mitochondrial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mitofusin 2 in Macrophages Links Mitochondrial...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Mitofusin 2 in Macrophages Links Mitochondrial...
questionsmedicales.fr › Phénomènes du système immunitaire › Phagocytose › Mitofusin 2 in Macrophages Links Mitochondrial...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Mitofusin 2 in Macrophages Links Mitochondrial...