MicroRNA predicts cognitive performance in healthy older adults.
Cognitive aging
Machine learning
Neurocognitive function
miRNA
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
21
01
2020
revised:
01
07
2020
accepted:
25
07
2020
pubmed:
28
8
2020
medline:
10
7
2021
entrez:
27
8
2020
Statut:
ppublish
Résumé
The expression of microRNA (miRNA) is influenced by ongoing biological processes, including aging, and has begun to play a role in the measurement of neurodegenerative processes in central nervous system. The purpose of this study is to utilize machine learning approaches to determine whether miRNA can be utilized as a blood-based biomarker of cognitive aging. A random forest regression combining miRNA with biological (brain volume), clinical (comorbid conditions), and demographic variables in 115 typically aging older adults explained the greatest level of variance in cognitive performance compared to the other machine learning models explored. Three miRNA (miR-140-5p, miR-197-3p, and miR-501-3p) were top-ranked predictors of multiple cognitive outcomes (Fluid, Crystallized, and Overall Cognition) and past studies of these miRNA link them to cellular senescence, inflammatory signals for atherosclerotic formation, and potential development of neurodegenerative disorders (e.g., Alzheimer's disease). Several novel miRNAs were also linked to age and multiple cognitive functions, findings which together warrant further exploration linking these miRNAs to brain-derived metrics of neurodegeneration in typically aging older adults.
Identifiants
pubmed: 32846274
pii: S0197-4580(20)30240-2
doi: 10.1016/j.neurobiolaging.2020.07.023
pmc: PMC7606424
mid: NIHMS1623716
pii:
doi:
Substances chimiques
Biomarkers
0
MicroRNAs
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
186-194Subventions
Organisme : NIAAA NIH HHS
ID : K01 AA025306
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG052258
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG036800
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG049711
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG037984
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054077
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066506
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG050707
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG047266
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG028740
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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