Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors.
Antibodies, Monoclonal
/ analysis
Antibodies, Monoclonal, Humanized
/ chemistry
Aptamers, Nucleotide
/ chemistry
Betacoronavirus
/ isolation & purification
Biosensing Techniques
/ methods
COVID-19
Coronavirus Infections
/ diagnosis
Humans
Immunoglobulin Fab Fragments
/ analysis
Interleukin-6
/ analysis
Limit of Detection
Pandemics
Pneumonia, Viral
/ diagnosis
Receptors, Interleukin-6
/ analysis
SARS-CoV-2
IL-6 cytokine
Proteotronics
aptamers
biosensors
topological analysis
Journal
Biosensors
ISSN: 2079-6374
Titre abrégé: Biosensors (Basel)
Pays: Switzerland
ID NLM: 101609191
Informations de publication
Date de publication:
24 Aug 2020
24 Aug 2020
Historique:
received:
15
07
2020
revised:
15
08
2020
accepted:
21
08
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
4
9
2020
Statut:
epublish
Résumé
Cytokines are a family of proteins which play a major role in the regulation of the immune system and the development of several diseases, from rheumatoid arthritis to cancer and, more recently, COVID-19. Therefore, many efforts are currently being developed to improve therapy and diagnosis, as well as to produce inhibitory drugs and biosensors for a rapid, minimally invasive, and effective detection. In this regard, even more efficient cytokine receptors are under investigation. In this paper we analyze a set of IL-6 cytokine receptors, investigating their topological features by means of a theoretical approach. Our results suggest a topological indicator that may help in the identification of those receptors having the highest complementarity with the protein, a feature expected to ensure a stable binding. Furthermore, we propose and discuss the use of these receptors in an idealized experimental setup.
Identifiants
pubmed: 32847008
pii: bios10090106
doi: 10.3390/bios10090106
pmc: PMC7557795
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Monoclonal, Humanized
0
Aptamers, Nucleotide
0
Immunoglobulin Fab Fragments
0
Interleukin-6
0
Receptors, Interleukin-6
0
olokizumab
PAI71R1D2W
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : FFABR 2017
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