Proteoglycans in the Pathogenesis of Hormone-Dependent Cancers: Mediators and Effectors.
breast cancer
hormone-dependent tumors
immunosurveillance
prostate cancer
proteoglycans
tumor biology
tumor microenvironment
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
24 Aug 2020
24 Aug 2020
Historique:
received:
15
07
2020
revised:
16
08
2020
accepted:
18
08
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
28
8
2020
Statut:
epublish
Résumé
Hormone-dependent cancers exhibit high morbidity and mortality. In spite of advances in therapy, the treatment of hormone-dependent cancers remains an unmet health need. The tumor microenvironment (TME) exhibits unique characteristics that differ among various tumor types. It is composed of cancerous, non-cancerous, stromal, and immune cells that are surrounded and supported by components of the extracellular matrix (ECM). Therefore, the interactions among cancer cells, stromal cells, and components of the ECM determine cancer progression and response to therapy. Proteoglycans (PGs), hybrid molecules consisting of a protein core to which sulfated glycosaminoglycan chains are bound, are significant components of the ECM that are implicated in all phases of tumorigenesis. These molecules, secreted by both the stroma and cancer cells, are crucial signaling mediators that modulate the vital cellular pathways implicated in gene expression, phenotypic versatility, and response to therapy in specific tumor types. A plethora of deregulated signaling pathways contributes to the growth, dissemination, and angiogenesis of hormone-dependent cancers. Specific inputs from the endocrine and immune systems are some of the characteristics of hormone-dependent cancer pathogenesis. Importantly, the mechanisms involved in various aspects of cancer progression are executed in the ECM niche of the TME, and the PG components crucially mediate these processes. Here, we comprehensively discuss the mechanisms through which PGs affect the multifaceted aspects of hormone-dependent cancer development and progression, including cancer metastasis, angiogenesis, immunobiology, autophagy, and response to therapy.
Identifiants
pubmed: 32847060
pii: cancers12092401
doi: 10.3390/cancers12092401
pmc: PMC7563227
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : ELKE UOC
ID : KA10028
Organisme : Ministerul Cercetării şi Inovării
ID : PN-III-P1-1.2-PCCDI-2017-0341/2018
Organisme : Mendeleev University of Chemical Technology
ID : Project Number K-2020-018
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