Breast Tumor Cell Invasion and Pro-Invasive Activity of Cancer-Associated Fibroblasts Co-Targeted by Novel Urokinase-Derived Decapeptides.
breast cancer cell invasion
cancer-associated fibroblasts
metastatic dissemination
tumor microenvironment
αv integrin
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
24 Aug 2020
24 Aug 2020
Historique:
received:
12
05
2020
revised:
11
08
2020
accepted:
19
08
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
28
8
2020
Statut:
epublish
Résumé
Among peritumoral cells, cancer-associated fibroblasts (CAFs) are major facilitators of tumor progression. This study describes the effects of two urokinase-derived, novel decapeptides, denoted as Pep 1 and its cyclic derivative Pep 2. In a mouse model of tumor dissemination, using HT1080 fibrosarcoma cells, Pep 2 reduced the number and size of lung metastases. Specific binding of fluoresceinated Pep 2 to HT1080 and telomerase immortalised fibroblasts (TIF) cell surfaces was enhanced by αv overexpression or abolished by excess vitronectin, anti-αv antibodies or silencing of
Identifiants
pubmed: 32847144
pii: cancers12092404
doi: 10.3390/cancers12092404
pmc: PMC7564779
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Regione Campania
ID : Combattere la resistenza tumorale: piattaforma integrata multidisciplinare per un approccio tecnologico innovativo alle oncoterapie - Campania Oncoterapie-B61G18000470007
Organisme : Regione Campania
ID : Sviluppo di Approcci Terapeutici INnovativi per patolgie neoplastiche resistenti ai trattamenti - POR SATIN
Organisme : Consiglio Nazionale delle Ricerche
ID : Flagship Project InterOmics
Organisme : International Society of Fibrinolysis and Proteolysis
ID : Fellowships to S.B. and A.D.V.
Organisme : Società Italiana di Biofisica e Biologia Molecolare SIBBM
ID : Fellowships to S.B. and A.D.V
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