A longitudinal study of the post-stroke immune response and cognitive functioning: the StrokeCog study protocol.
Cognition
Immune system
Neuropsychology
Proteomics
Stroke
Vascular dementia
Journal
BMC neurology
ISSN: 1471-2377
Titre abrégé: BMC Neurol
Pays: England
ID NLM: 100968555
Informations de publication
Date de publication:
26 Aug 2020
26 Aug 2020
Historique:
received:
22
07
2020
accepted:
20
08
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
24
11
2020
Statut:
epublish
Résumé
Stroke increases the risk of cognitive impairment even several years after the stroke event. The exact mechanisms of post-stroke cognitive decline are unclear, but the immunological response to stroke might play a role. The aims of the StrokeCog study are to examine the associations between immunological responses and long-term post-stroke cognitive trajectories in individuals with ischemic stroke. StrokeCog is a single-center, prospective, observational, cohort study. Starting 6-12 months after stroke, comprehensive neuropsychological assessment, plasma and serum, and psychosocial variables will be collected at up to 4 annual visits. Single cell sequencing of peripheral blood monocytes and plasma proteomics will be conducted. The primary outcome will be the change in global and domain-specific neuropsychological performance across annual evaluations. To explain the differences in cognitive change amongst participants, we will examine the relationships between comprehensive immunological measures and these cognitive trajectories. It is anticipated that 210 participants will be enrolled during the first 3 years of this 4-year study. Accounting for attrition, an anticipated final sample size of 158 participants with an average of 3 annual study visits will be available at the completion of the study. Power analyses indicate that this sample size will provide 90% power to detect an average cognitive change of at least 0.23 standard deviations in either direction. StrokeCog will provide novel insight into the relationships between immune events and cognitive change late after stroke.
Sections du résumé
BACKGROUND
BACKGROUND
Stroke increases the risk of cognitive impairment even several years after the stroke event. The exact mechanisms of post-stroke cognitive decline are unclear, but the immunological response to stroke might play a role. The aims of the StrokeCog study are to examine the associations between immunological responses and long-term post-stroke cognitive trajectories in individuals with ischemic stroke.
METHODS
METHODS
StrokeCog is a single-center, prospective, observational, cohort study. Starting 6-12 months after stroke, comprehensive neuropsychological assessment, plasma and serum, and psychosocial variables will be collected at up to 4 annual visits. Single cell sequencing of peripheral blood monocytes and plasma proteomics will be conducted. The primary outcome will be the change in global and domain-specific neuropsychological performance across annual evaluations. To explain the differences in cognitive change amongst participants, we will examine the relationships between comprehensive immunological measures and these cognitive trajectories. It is anticipated that 210 participants will be enrolled during the first 3 years of this 4-year study. Accounting for attrition, an anticipated final sample size of 158 participants with an average of 3 annual study visits will be available at the completion of the study. Power analyses indicate that this sample size will provide 90% power to detect an average cognitive change of at least 0.23 standard deviations in either direction.
DISCUSSION
CONCLUSIONS
StrokeCog will provide novel insight into the relationships between immune events and cognitive change late after stroke.
Identifiants
pubmed: 32847540
doi: 10.1186/s12883-020-01897-9
pii: 10.1186/s12883-020-01897-9
pmc: PMC7448308
doi:
Types de publication
Clinical Trial Protocol
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
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