β2 Integrins differentially regulate γδ T cell subset thymic development and peripheral maintenance.
immune homeostasis
β2 integrins
γδ T cells
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
08 09 2020
08 09 2020
Historique:
pubmed:
28
8
2020
medline:
31
10
2020
entrez:
28
8
2020
Statut:
ppublish
Résumé
The γδ T cells reside predominantly at barrier sites and play essential roles in immune protection against infection and cancer. Despite recent advances in the development of γδ T cell immunotherapy, our understanding of the basic biology of these cells, including how their numbers are regulated in vivo, remains poor. This is particularly true for tissue-resident γδ T cells. We have identified the β
Identifiants
pubmed: 32848068
pii: 1921930117
doi: 10.1073/pnas.1921930117
pmc: PMC7486781
doi:
Substances chimiques
CD18 Antigens
0
Il17a protein, mouse
0
Interleukin-17
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
22367-22377Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 20848
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 20848
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204820/Z/16/Z
Pays : United Kingdom
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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