Chromatic Pupillometry Findings in Alzheimer's Disease.
Alzheimer’s disease
chromatic pupillometry
melanopsin retinal ganglion cells
post-illumination pupil response
pupil
pupillary light reflex
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2020
2020
Historique:
received:
09
05
2020
accepted:
02
07
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
28
8
2020
Statut:
epublish
Résumé
Intrinsically photosensitive melanopsin retinal ganglion cells (mRGCs) are crucial for non-image forming functions of the eye, including the photoentrainment of circadian rhythms and the regulation of the pupillary light reflex (PLR). Chromatic pupillometry, using light stimuli at different wavelengths, makes possible the isolation of the contribution of rods, cones, and mRGCs to the PLR. In particular, post-illumination pupil response (PIPR) is the most reliable pupil metric of mRGC function. We have previously described, in post-mortem investigations of AD retinas, a loss of mRGCs, and in the remaining mRGCs, we demonstrated extensive morphological abnormalities. We noted dendrite varicosities, patchy distribution of melanopsin, and reduced dendrite arborization. In this study, we evaluated, with chromatic pupillometry, the PLR in a cohort of mild-moderate AD patients compared to controls. AD and controls also underwent an extensive ophthalmological evaluation. In our AD cohort, PIPR did not significantly differ from controls, even though we observed a higher variability in the AD group and 5/26 showed PIPR values outside the 2 SD from the control mean values. Moreover, we found a significant difference between AD and controls in terms of rod-mediated transient PLR amplitude. These results suggest that in the early stage of AD there are PLR abnormalities that may reflect a pathology affecting mRGC dendrites before involving the mRGC cell body. Further studies, including AD cases with more severe and longer disease duration, are needed to further explore this hypothesis.
Identifiants
pubmed: 32848556
doi: 10.3389/fnins.2020.00780
pmc: PMC7431959
doi:
Types de publication
Journal Article
Langues
eng
Pagination
780Informations de copyright
Copyright © 2020 Romagnoli, Stanzani Maserati, De Matteis, Capellari, Carbonelli, Amore, Cantalupo, Zenesini, Liguori, Sadun, Carelli, Park and La Morgia.
Références
J Comp Neurol. 2014 Jul 1;522(10):2231-48
pubmed: 24752373
Invest Ophthalmol Vis Sci. 2011 Aug 22;52(9):6624-35
pubmed: 21743008
J Neurosci. 2002 Jan 1;22(1):RC191
pubmed: 11756521
Front Neurol. 2019 Feb 22;10:129
pubmed: 30853933
J Comp Neurol. 2017 Jun 1;525(8):1934-1961
pubmed: 28160289
Neurol Sci. 2003 Feb;23(6):295-300
pubmed: 12624716
Ophthalmology. 2011 Feb;118(2):376-81
pubmed: 20869119
J Ophthalmol. 2017;2017:7935406
pubmed: 28894607
Neurobiol Aging. 2013 Jul;34(7):1799-806
pubmed: 23465714
Arch Gen Psychiatry. 1961 Jun;4:561-71
pubmed: 13688369
Br J Ophthalmol. 2019 Jul;103(7):971-975
pubmed: 30206156
J Comp Neurol. 2018 Sep 1;526(13):2010-2018
pubmed: 29888785
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Vision Res. 2020 Mar;168:53-63
pubmed: 32088401
Int J Psychophysiol. 2003 Feb;47(2):95-115
pubmed: 12568941
Psychiatry Res. 1989 May;28(2):193-213
pubmed: 2748771
Front Neurol. 2019 Apr 12;10:360
pubmed: 31031692
Sci Rep. 2018 Nov 5;8(1):16345
pubmed: 30397251
Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3812-20
pubmed: 17652756
Vision Res. 2010 Jan;50(1):72-87
pubmed: 19850061
PLoS One. 2013 Jun 07;8(6):e66480
pubmed: 23762490
Brain Res. 1984 Jun 8;302(2):371-7
pubmed: 6733517
Lancet. 2007 Oct 20;370(9596):1453-7
pubmed: 18064739
Ann Neurol. 2016 Jan;79(1):90-109
pubmed: 26505992
Aging (Milano). 2001 Dec;13(6):473-8
pubmed: 11845975
Ageing Res Rev. 2020 Jul;60:101046
pubmed: 32171783
Front Neurol. 2017 May 04;8:162
pubmed: 28522986
Front Aging Neurosci. 2017 Apr 04;9:79
pubmed: 28420980
Sci Rep. 2015 Dec 01;5:17610
pubmed: 26620343
Science. 2002 Feb 8;295(5557):1065-70
pubmed: 11834834
Brain. 2010 Oct;133(10):2942-51
pubmed: 20817698
PLoS One. 2019 Dec 10;14(12):e0226197
pubmed: 31821378
Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2501-8
pubmed: 27152964
J Consult Clin Psychol. 1988 Dec;56(6):893-7
pubmed: 3204199
Eur J Neurosci. 2003 Dec;18(11):3007-17
pubmed: 14656296
Brain. 2004 May;127(Pt 5):1061-74
pubmed: 14998915
Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3838-49
pubmed: 26066752
Lancet Neurol. 2014 Jun;13(6):614-29
pubmed: 24849862
Eur J Neurosci. 2008 Apr;27(7):1763-70
pubmed: 18371076
Science. 2002 Feb 8;295(5557):1070-3
pubmed: 11834835
Sci Rep. 2017 Mar 23;7:44987
pubmed: 28332564
J Neurol Neurosurg Psychiatry. 1997 Jun;62(6):665-8
pubmed: 9219763
Curr Alzheimer Res. 2013 Oct;10(8):790-6
pubmed: 23919771
JCI Insight. 2017 Aug 17;2(16):
pubmed: 28814675
Int J Psychophysiol. 2000 Jul;37(1):111-20
pubmed: 10828379
Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4202-9
pubmed: 15505076
Front Neurol. 2018 Dec 07;9:1047
pubmed: 30581410
Neurology. 1984 Jul;34(7):939-44
pubmed: 6610841
Pain. 2014 Feb;155(2):210-6
pubmed: 24334188
Aging Clin Exp Res. 2007 Oct;19(5):364-71
pubmed: 18007114
Neuron. 2019 Oct 23;104(2):205-226
pubmed: 31647894
J Alzheimers Dis. 2020;75(4):1273-1282
pubmed: 32417780
Int J Psychophysiol. 2009 Aug;73(2):143-9
pubmed: 19414041
J Alzheimers Dis. 2014;42(4):1469-77
pubmed: 25024346
Sci Rep. 2017 Mar 07;7:43832
pubmed: 28266650
Nature. 2011 Jul 17;476(7358):92-5
pubmed: 21765429
Curr Alzheimer Res. 2013 Nov;10(9):931-9
pubmed: 24117119