Rising Stars: Astrocytes as a Therapeutic Target for ALS Disease.
A1 astrocyte
A2 astrocyte
TDP-43 aggregates
amyotrophic lateral sclerosis
astrocyte cell-based therapy
astrocytes
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
05
2020
accepted:
14
07
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
28
8
2020
Statut:
epublish
Résumé
Amyotrophic lateral sclerosis (ALS) is a multifactorial disease, characterized by a progressive loss of motor neurons that eventually leads to paralysis and death. The current ALS-approved drugs modestly change the clinical course of the disease. The mechanism by which motor neurons progressively degenerate remains unclear but entails a non-cell autonomous process. Astrocytes impaired biological functionality were implicated in multiple neurodegenerative diseases, including ALS, frontotemporal dementia (FTD), Parkinson's disease (PD), and Alzheimer disease (AD). In ALS disease patients, A1 reactive astrocytes were found to play a key role in the pathology of ALS disease and death of motor neurons, via loss or gain of function or acquired toxicity. The contribution of astrocytes to the maintenance of motor neurons by diverse mechanisms makes them a promising therapeutic candidate for the treatment of ALS. Therapeutic approaches targeting at modulating the function of endogenous astrocytes or replacing lost functionality by transplantation of healthy astrocytes, may contribute to the development of therapies which might slow down or even halt the progression ALS diseases. The proposed mechanisms by which astrocytes can potentially ameliorate ALS progression and the status of ALS clinical studies involving astrocytes are discussed.
Identifiants
pubmed: 32848579
doi: 10.3389/fnins.2020.00824
pmc: PMC7399224
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
824Informations de copyright
Copyright © 2020 Izrael, Slutsky and Revel.
Références
Acta Neuropathol. 2013 Sep;126(3):401-9
pubmed: 23818065
Immunity. 2017 Jun 20;46(6):957-967
pubmed: 28636962
J Biol Chem. 2016 May 13;291(20):10836-46
pubmed: 27002158
Lancet Neurol. 2013 May;12(5):435-42
pubmed: 23541756
J Neural Transm (Vienna). 2011 Apr;118(4):531-8
pubmed: 21069391
Acta Neuropathol. 2018 Jan;135(1):155-156
pubmed: 29052003
Brain. 2020 Feb 1;143(2):430-440
pubmed: 32040555
Front Neurosci. 2018 Jul 19;12:487
pubmed: 30072868
J Mol Neurosci. 2009 Sep;39(1-2):199-210
pubmed: 19127447
Neuron. 2011 Oct 20;72(2):257-68
pubmed: 21944779
Trends Mol Med. 2016 Sep;22(9):769-783
pubmed: 27498188
Cell Rep. 2016 Oct 11;17(3):645-652
pubmed: 27732842
Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):829-32
pubmed: 24379375
Front Mol Neurosci. 2019 Nov 01;12:262
pubmed: 31736708
Stem Cell Reports. 2014 Aug 12;3(2):242-9
pubmed: 25254338
EBioMedicine. 2019 Feb;40:626-635
pubmed: 30711519
Exp Neurol. 2008 Jun;211(2):423-32
pubmed: 18410928
Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E756-65
pubmed: 23388633
J Clin Invest. 2014 Mar;124(3):1255-67
pubmed: 24569372
Science. 2009 Feb 27;323(5918):1208-1211
pubmed: 19251628
Mol Ther. 2008 Dec;16(12):2002-10
pubmed: 18797452
Glia. 2018 Nov;66(11):2340-2352
pubmed: 30144323
Cell Stem Cell. 2008 Dec 4;3(6):649-57
pubmed: 19041781
Curr Opin Neurobiol. 2017 Aug;45:113-120
pubmed: 28570864
PLoS One. 2007 Aug 01;2(8):e689
pubmed: 17668067
J Neurogenet. 2017 Mar - Jun;31(1-2):37-48
pubmed: 28019127
Mol Ther Nucleic Acids. 2019 Mar 1;14:593-608
pubmed: 30776581
Mol Med. 2012 Jul 18;18:794-804
pubmed: 22481270
Curr Alzheimer Res. 2011 May;8(3):273-94
pubmed: 21222600
Acta Neuropathol. 2013 Dec;126(6):881-93
pubmed: 24132570
Nat Neurosci. 2005 Jan;8(1):85-92
pubmed: 15568021
Nat Rev Neurosci. 2013 Apr;14(4):248-64
pubmed: 23463272
Biochem Biophys Res Commun. 2006 Dec 22;351(3):602-11
pubmed: 17084815
Glia. 2018 May;66(5):1016-1033
pubmed: 29380416
Nat Biotechnol. 2011 Aug 10;29(9):824-8
pubmed: 21832997
Mol Ther. 2013 Aug;21(8):1602-10
pubmed: 23712039
Neuroscientist. 2019 Jun;25(3):227-240
pubmed: 29931997
Nature. 1993 Mar 4;362(6415):59-62
pubmed: 8446170
FASEB J. 2019 Jun;33(6):7084-7091
pubmed: 30841754
Neurosci Lett. 2017 Jan 1;636:16-26
pubmed: 27619540
Stem Cells Transl Med. 2015 Jun;4(6):590-7
pubmed: 25934946
Front Neurosci. 2019 Jun 27;13:532
pubmed: 31316328
EMBO J. 2016 Feb 1;35(3):239-57
pubmed: 26758544
N Engl J Med. 2001 May 31;344(22):1688-700
pubmed: 11386269
J Neurosci. 2008 Dec 10;28(50):13574-81
pubmed: 19074031
Acta Neuropathol. 2017 Jul;134(1):113-127
pubmed: 28527045
Amyotroph Lateral Scler Frontotemporal Degener. 2017 May;18(3-4):269-278
pubmed: 28166654
Nat Neurosci. 2007 May;10(5):608-14
pubmed: 17435754
Cells. 2019 Apr 03;8(4):
pubmed: 30987213
Cell. 2015 Aug 27;162(5):1170-1170.e1
pubmed: 26317476
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2933-8
pubmed: 19196989
Neuron. 2011 Oct 20;72(2):245-56
pubmed: 21944778
Stem Cell Res Ther. 2018 Jun 6;9(1):152
pubmed: 29871694
Amyotroph Lateral Scler. 2007 Apr;8(2):79-82
pubmed: 17453633
Neurology. 2019 Dec 10;93(24):e2294-e2305
pubmed: 31740545
Nat Neurosci. 2014 Jan;17(1):131-43
pubmed: 24316888
Front Mol Neurosci. 2019 Feb 14;12:25
pubmed: 30837838
Science. 2009 Feb 27;323(5918):1205-8
pubmed: 19251627
Front Aging Neurosci. 2017 Jul 25;9:242
pubmed: 28790913
J Clin Invest. 2017 Sep 1;127(9):3210-3219
pubmed: 28862640
Physiol Rev. 2019 Jan 1;99(1):21-78
pubmed: 30280653
Science. 1999 Apr 2;284(5411):143-7
pubmed: 10102814
J Cell Biol. 2009 Dec 14;187(6):761-72
pubmed: 19951898
PLoS One. 2011;6(10):e25968
pubmed: 21998733
Cell Death Differ. 2011 May;18(5):754-68
pubmed: 21072055
Neurobiol Aging. 2010 Dec;31(12):2185-91
pubmed: 19185395
Nature. 2005 Jan 6;433(7021):73-7
pubmed: 15635412
Neuroscience. 2013 Sep 17;248:333-43
pubmed: 23727509
Acta Neuropathol. 2013 Dec;126(6):845-57
pubmed: 24170096
EBioMedicine. 2019 Dec;50:274-289
pubmed: 31787569
Neurobiol Aging. 2009 Dec;30(12):1924-35
pubmed: 18375019
Trends Biochem Sci. 2007 Jan;32(1):12-9
pubmed: 17161604
Neurosci Lett. 2017 Aug 24;656:120-125
pubmed: 28732762
Neuron. 2014 Jul 16;83(2):309-323
pubmed: 24952961
Cell Stem Cell. 2008 Dec 4;3(6):637-48
pubmed: 19041780
Nat Rev Neurol. 2011 Oct 11;7(11):639-49
pubmed: 21989247
Glia. 2011 Jun;59(6):946-58
pubmed: 21446050
Brain. 2011 Sep;134(Pt 9):2627-41
pubmed: 21908873
Acta Neuropathol. 2019 Jan;137(1):1-26
pubmed: 30368547
Nat Neurosci. 2012 Nov;15(11):1488-97
pubmed: 23023293
Brain. 2019 May 1;142(5):1176-1194
pubmed: 30938443
Front Pharmacol. 2019 Dec 02;10:1452
pubmed: 31849688
Front Physiol. 2019 Apr 26;10:486
pubmed: 31105589
Brain Res Bull. 1994;35(5-6):403-7
pubmed: 7532097
Neurosci Lett. 2019 Jun 21;704:201-207
pubmed: 30978452
Hum Mol Genet. 2012 Feb 15;21(4):826-40
pubmed: 22072391
Brain Pathol. 2017 Sep;27(5):629-644
pubmed: 28805002
Acta Neuropathol. 2018 Apr;135(4):489-509
pubmed: 29549424
Ann Neurol. 2015 Jun;77(6):942-52
pubmed: 25707479
J Neuroinflammation. 2016 Aug 30;13(1):212
pubmed: 27578023
Lancet. 2011 Mar 12;377(9769):942-55
pubmed: 21296405
Stem Cells. 2018 Jul;36(7):1122-1131
pubmed: 29656478
Curr Alzheimer Res. 2006 Feb;3(1):19-24
pubmed: 16472198
Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361(1473):1545-64
pubmed: 16939974
J Neurosci Res. 2003 Dec 15;74(6):801-6
pubmed: 14648584
Science. 2013 Mar 15;339(6125):1335-8
pubmed: 23393093
Neurodegener Dis. 2017;17(1):44-58
pubmed: 27617773
Aging Cell. 2016 Jun;15(3):522-30
pubmed: 26970090
Brain Res Rev. 2011 Jun 24;67(1-2):1-39
pubmed: 20971133
Lancet Neurol. 2017 Jul;16(7):505-512
pubmed: 28522181
Hum Gene Ther. 2005 Apr;16(4):509-21
pubmed: 15871682
Neurobiol Dis. 2006 Mar;21(3):556-67
pubmed: 16274998
Cell Rep. 2015 Apr 28;11(4):592-604
pubmed: 25892237
Acta Neuropathol. 2014 Mar;127(3):441-50
pubmed: 24240737
Mol Ther Nucleic Acids. 2019 Jun 7;16:26-37
pubmed: 30825670
Neuron. 2017 Nov 1;96(3):697-708
pubmed: 29096081
Exp Neurol. 2008 Oct;213(2):448-55
pubmed: 18718468
Eur J Neurosci. 2000 Dec;12(12):4243-54
pubmed: 11122336
Nat Neurosci. 2008 Mar;11(3):251-3
pubmed: 18246065
Science. 2006 Oct 6;314(5796):130-3
pubmed: 17023659
J Neurosci Res. 2009 Jul;87(9):2034-46
pubmed: 19267424
Nat Rev Neurosci. 2004 May;5(5):409-19
pubmed: 15100723
J Neurochem. 2018 Feb 27;:
pubmed: 29486049
Expert Opin Ther Targets. 2013 Sep;17(9):991-5
pubmed: 23844663