Stabilization of HIF-1α in Human Retinal Endothelial Cells Modulates Expression of miRNAs and Proangiogenic Growth Factors.
diabetic retinopathy
hypoxia-inducible-factor-1α
inflammation
retina
transforming growth factor beta
vascular endothelial growth factor
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
16
03
2020
accepted:
30
06
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
28
8
2020
Statut:
epublish
Résumé
Retinal hypoxia is one of the causative factors of diabetic retinopathy and is also one of the triggers of VEGF release. We hypothesized that specific dysregulated miRNAs in diabetic retinopathy could be linked to hypoxia-induced damage in human retinal endothelial cells (HRECs). We investigated in HRECs the effects of chemical (CoCl
Identifiants
pubmed: 32848728
doi: 10.3389/fphar.2020.01063
pmc: PMC7396674
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1063Informations de copyright
Copyright © 2020 Lazzara, Trotta, Platania, D’Amico, Petrillo, Galdiero, Gesualdo, Rossi, Drago and Bucolo.
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