Osteoimmunology: The Regulatory Roles of T Lymphocytes in Osteoporosis.
T lymphocytes
bone formation
bone resorption
osteoimmunology
osteoporosis
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2020
2020
Historique:
received:
31
12
2019
accepted:
15
06
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
18
5
2021
Statut:
epublish
Résumé
Immune imbalance caused bone loss. Osteoimmunology is emerging as a new interdisciplinary field to explore the shared molecules and interactions between the skeletal and immune systems. In particular, T lymphocytes (T cells) play pivotal roles in the regulation of bone health. However, the roles and mechanisms of T cells in the treatment of osteoporosis are not fully understood. The present review aims to summarize the essential regulatory roles of T cells in the pathophysiology of various cases of osteoporosis and the development of T cell therapy for osteoporosis from osteoimmunology perspective. As T cell-mediated immunomodulation inhibition reduced bone loss, there is an increasing interest in T cell therapy in an attempt to treat osteoporosis. In summary, the T cell therapy may be further pursued as an immunomodulatory strategy for the treatment of osteoporosis, which can provide a novel perspective for drug development in the future.
Identifiants
pubmed: 32849268
doi: 10.3389/fendo.2020.00465
pmc: PMC7431602
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
465Informations de copyright
Copyright © 2020 Zhang, Dang, Huai and Qian.
Références
Nat Rev Rheumatol. 2015 Feb;11(2):74-6
pubmed: 25561367
Front Immunol. 2014 Oct 20;5:511
pubmed: 25368616
J Investig Med. 2017 Aug;65(6):1014-1020
pubmed: 28634253
Nat Rev Endocrinol. 2010 Dec;6(12):698-706
pubmed: 21045788
Front Endocrinol (Lausanne). 2018 Sep 04;9:510
pubmed: 30214430
J Bone Miner Res. 2016 Nov;31(11):1997-2000
pubmed: 27207251
Sci Rep. 2018 Feb 6;8(1):2503
pubmed: 29410520
Nat Rev Rheumatol. 2009 Dec;5(12):667-76
pubmed: 19884898
J Immunol. 2008 Mar 15;180(6):3661-9
pubmed: 18322171
Gynecol Endocrinol. 2015 Mar;31(3):183-90
pubmed: 25384921
Arthritis Res Ther. 2010;12(1):R29
pubmed: 20167120
Eur J Clin Invest. 2013 Nov;43(11):1195-202
pubmed: 24033116
Cold Spring Harb Perspect Med. 2019 Jan 2;9(1):
pubmed: 29610150
Future Oncol. 2018 Feb;14(3):191-194
pubmed: 29334785
Exp Gerontol. 2020 Feb 22;134:110887
pubmed: 32092501
J Exp Med. 2006 Nov 27;203(12):2673-82
pubmed: 17088434
Curr Osteoporos Rep. 2013 Dec;11(4):257-62
pubmed: 24085651
Cell Metab. 2015 Nov 3;22(5):799-810
pubmed: 26456334
J Bone Miner Res. 2017 Dec;32(12):2476-2488
pubmed: 28771888
J Bone Miner Res. 2014 Jan;29(1):43-54
pubmed: 24357520
Front Endocrinol (Lausanne). 2019 Sep 10;10:578
pubmed: 31551927
Cell Mol Immunol. 2011 Jan;8(1):50-8
pubmed: 21200384
J Bone Miner Res. 2012 Oct;27(10):2075-84
pubmed: 22623172
Cell Metab. 2010 Jun 9;11(6):517-31
pubmed: 20519123
J Cell Physiol. 2017 Dec;232(12):3396-3408
pubmed: 28059444
Biomed Pharmacother. 2019 Jul;115:108850
pubmed: 31004988
Curr Opin Immunol. 2006 Jun;18(3):349-56
pubmed: 16616472
Nutr Rev. 2007 Dec;65(12 Pt 2):S147-51
pubmed: 18240539
Baillieres Best Pract Res Clin Endocrinol Metab. 2000 Jun;14(2):279-98
pubmed: 11035907
Immun Ageing. 2005 Nov 04;2:14
pubmed: 16271143
Bone. 2013 Sep;56(1):163-73
pubmed: 23756229
PLoS One. 2012;7(9):e44552
pubmed: 22970248
Clin Exp Immunol. 2017 Jul;189(1):1-11
pubmed: 28419440
Endocrinology. 2003 Aug;144(8):3524-31
pubmed: 12865334
Biochem Biophys Res Commun. 2010 Nov 12;402(2):173-6
pubmed: 20920469
Free Radic Biol Med. 2014 Dec;77:10-20
pubmed: 25224042
J Anthropol Sci. 2014;92:119-46
pubmed: 24607995
Nat Commun. 2020 Jan 24;11(1):468
pubmed: 31980603
Food Funct. 2019 Oct 16;10(10):6556-6567
pubmed: 31549110
Trends Immunol. 2011 Sep;32(9):428-33
pubmed: 21723783
Arthritis Rheum. 2006 Jan;54(1):68-75
pubmed: 16385497
Nat Rev Endocrinol. 2016 Sep;12(9):518-32
pubmed: 27312863
Inflamm Res. 2006 Oct;55(10):399-404
pubmed: 17109066
Bone. 2003 Oct;33(4):721-32
pubmed: 14555278
Sci Rep. 2017 Apr 06;7:45964
pubmed: 28382965
Reumatol Clin. 2013 Sep-Oct;9(5):303-15
pubmed: 23727459
Bone. 2018 Dec;117:161-170
pubmed: 30236554
Sci Rep. 2018 Apr 4;8(1):5625
pubmed: 29618833
Eur J Immunol. 2005 Nov;35(11):3353-63
pubmed: 16220542
J Bone Miner Res. 2018 Feb;33(2):241-249
pubmed: 29024045
Nat Rev Rheumatol. 2012 Nov;8(11):656-64
pubmed: 23007741
Biomed Pharmacother. 2018 Jun;102:369-374
pubmed: 29571022
Arthritis Rheum. 2007 Dec;56(12):4104-12
pubmed: 18050211
Lancet Diabetes Endocrinol. 2017 Jul;5(7):513-523
pubmed: 28546097
Mol Med Rep. 2016 Sep;14(3):2289-96
pubmed: 27430581
Immun Ageing. 2019 Aug 22;16:21
pubmed: 31462901
Nat Commun. 2015 Sep 22;6:8282
pubmed: 26392000
Bioconjug Chem. 2017 Nov 15;28(11):2772-2783
pubmed: 29040803
Immunity. 2009 Aug 21;31(2):184-96
pubmed: 19699170
Cold Spring Harb Perspect Med. 2018 Aug 1;8(8):
pubmed: 29358318
J Immunol Res. 2015;2015:108451
pubmed: 26000310
Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18525-30
pubmed: 24167272
Biochem Biophys Res Commun. 2018 May 15;499(3):648-654
pubmed: 29604276
Genet Mol Res. 2016 Sep 9;15(3):
pubmed: 27706709
Pediatr Infect Dis J. 2017 Jun;36(6):578-583
pubmed: 28005690
Front Immunol. 2018 Apr 05;9:657
pubmed: 29675022
J Clin Endocrinol Metab. 2005 Jun;90(6):3491-7
pubmed: 15797957
PLoS One. 2010 Aug 20;5(8):e12290
pubmed: 20808842
J Immunol. 1998 Dec 1;161(11):6113-21
pubmed: 9834095
Endocrinology. 2002 Mar;143(3):1108-18
pubmed: 11861538
Front Biosci (Landmark Ed). 2018 Jan 1;23:464-492
pubmed: 28930556
Front Endocrinol (Lausanne). 2019 Jan 08;9:788
pubmed: 30671025
Arthritis Res Ther. 2007;9(2):102
pubmed: 17349065
Curr Osteoporos Rep. 2017 Jun;15(3):135-141
pubmed: 28421466
J Bone Miner Metab. 2019 Jan;37(1):2-8
pubmed: 30324535
Osteoporos Int. 2019 Jul;30(7):1501-1510
pubmed: 30915506
Nature. 2000 Nov 30;408(6812):600-5
pubmed: 11117749
Ann N Y Acad Sci. 2016 Jan;1364:11-24
pubmed: 26662934
J Immunol. 2005 Jul 15;175(2):917-25
pubmed: 16002690
N Engl J Med. 2011 Jul 7;365(1):62-70
pubmed: 21732837
Physiol Rev. 2017 Oct 1;97(4):1295-1349
pubmed: 28814613
Bone. 2010 Sep;47(3):461-71
pubmed: 20452473
J Bone Miner Metab. 2002;20(5):266-8
pubmed: 12203031
Neth J Med. 2017 May;75(4):138-144
pubmed: 28522769
Bone Rep. 2018 Feb 05;8:46-56
pubmed: 29955622
Cell Metab. 2017 Mar 7;25(3):661-672
pubmed: 28162969
Annu Rev Immunol. 2002;20:795-823
pubmed: 11861618
Arthritis Res Ther. 2011 Jul 28;13(4):235
pubmed: 21861862
Arch Biochem Biophys. 2008 May 15;473(2):139-46
pubmed: 18395508
Immune Netw. 2019 Feb 20;19(1):e2
pubmed: 30838157
Front Immunol. 2016 Feb 17;7:57
pubmed: 26925062
J Clin Invest. 2001 Jun;107(11):1375-85
pubmed: 11390419
Curr Osteoporos Rep. 2017 Jun;15(3):121-125
pubmed: 28432597
J Bone Miner Metab. 2018 Nov;36(6):648-660
pubmed: 29234953
Cell Adh Migr. 2010 Jan-Mar;4(1):4-6
pubmed: 19949313
Clin Rev Bone Miner Metab. 2018 Mar;16(1):33-47
pubmed: 29962904
Mayo Clin Proc. 2009 Jul;84(7):632-7; quiz 638
pubmed: 19567717
Trends Mol Med. 2016 Aug;22(8):641-644
pubmed: 27354328
Cytokine Growth Factor Rev. 2016 Oct;31:27-35
pubmed: 27235091
Bone Res. 2019 Aug 15;7:25
pubmed: 31646015
J Bone Miner Res. 2014 Nov;29(11):2520-6
pubmed: 24771492
Endocrine. 2018 Jul;61(1):7-16
pubmed: 29691807
Gerontology. 2015;61(6):534-42
pubmed: 25720990
Expert Opin Drug Metab Toxicol. 2015 Mar;11(3):461-70
pubmed: 25614274
J Immunol. 2001 Apr 15;166(8):4915-21
pubmed: 11290769
J Clin Invest. 2005 Feb;115(2):282-90
pubmed: 15668736
Blood. 2007 May 1;109(9):3839-48
pubmed: 17202317
RMD Open. 2018 Jun 17;4(1):e000631
pubmed: 30018797
Injury. 2017 Dec;48 Suppl 7:S34-S40
pubmed: 28882375
J Bone Miner Res. 2001 Nov;16(11):1948-52
pubmed: 11697790
Aging Cell. 2019 Aug;18(4):e12967
pubmed: 31120193