Bacteria Modify Their Sensitivity to Chemerin-Derived Peptides by Hindering Peptide Association With the Cell Surface and Peptide Oxidation.
antimicrobial peptide
chemerin
psoriasis
sigma factor
skin
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
05
2020
accepted:
10
07
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
28
8
2020
Statut:
epublish
Résumé
Chronic inflammatory skin diseases like psoriasis alter the local skin microbiome and lead to complications such as persistent infection with opportunistic/pathogenic bacteria. Disease-associated changes in microbiota may be due to downregulation of epidermal antimicrobial proteins/peptides, such as antimicrobial protein chemerin. Here, we show that chemerin and its bioactive derivatives have differential effects on the viability of different genera of cutaneous bacteria. The lethal effects of chemerin are enhanced by bacterial-derived ROS-induced chemerin peptide oxidation and suppressed by stationary phase sigma factor RpoS. Insight into the mechanisms underlying changes in the composition of cutaneous bacteria during autoreactive skin disease may provide novel ways to mobilize chemerin and its peptide derivatives for maximum antimicrobial efficacy.
Identifiants
pubmed: 32849424
doi: 10.3389/fmicb.2020.01819
pmc: PMC7431654
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1819Informations de copyright
Copyright © 2020 Godlewska, Bilska, Majewski, Pyza, Zabel and Cichy.
Références
Exp Hematol. 2006 Aug;34(8):1021-32
pubmed: 16863908
J Biol Chem. 2019 Jan 25;294(4):1267-1278
pubmed: 30504221
J Exp Med. 2009 Jan 16;206(1):249-58
pubmed: 19114666
PLoS One. 2008 Jul 23;3(7):e2719
pubmed: 18648509
J Biol Chem. 2005 Oct 14;280(41):34661-6
pubmed: 16096270
Arch Dermatol Res. 2012 Jan;304(1):15-22
pubmed: 22065152
Microbiome. 2018 Sep 5;6(1):154
pubmed: 30185226
Biochemistry. 2008 Nov 25;47(47):12365-70
pubmed: 18956890
J Am Acad Dermatol. 2005 Jul;53(1):67-72
pubmed: 15965423
J Immunol. 2005 Jan 1;174(1):244-51
pubmed: 15611246
J Immunol. 2007 Mar 15;178(6):3713-20
pubmed: 17339469
J Immunol. 2011 Aug 1;187(3):1403-10
pubmed: 21715684
Am J Clin Exp Immunol. 2014 Feb 27;3(1):1-19
pubmed: 24660117
J Biol Chem. 2007 Sep 21;282(38):28175-88
pubmed: 17635925
J Exp Med. 2003 Oct 6;198(7):977-85
pubmed: 14530373
J Bacteriol. 2016 Dec 28;199(2):
pubmed: 27821607
J Bacteriol. 2006 Aug;188(16):5693-703
pubmed: 16885437
Front Immunol. 2017 Mar 29;8:353
pubmed: 28424689
Biochim Biophys Acta Biomembr. 2019 Oct 1;1861(10):182990
pubmed: 31129116
Microb Biotechnol. 2019 Mar;12(2):392-404
pubmed: 30656833
Biochem J. 2013 Jun 1;452(2):271-80
pubmed: 23495698
J Biol Chem. 2011 Nov 11;286(45):39510-9
pubmed: 21949124
PLoS One. 2013;8(3):e58709
pubmed: 23527010
Biotechniques. 2010 Jun;48(6):463-5
pubmed: 20569222
Cytokine Growth Factor Rev. 2019 Oct;49:70-84
pubmed: 31473081
J Immunol. 2005 Jul 1;175(1):487-93
pubmed: 15972683
Front Microbiol. 2017 Oct 16;8:2000
pubmed: 29085349
J Biol Chem. 2015 Sep 25;290(39):23781-92
pubmed: 26245902