Regulation of the Bone Marrow Niche by Inflammation.
Adaptation, Biological
Animals
Bone Marrow
/ metabolism
Bone Marrow Cells
/ cytology
Cell Transformation, Neoplastic
/ genetics
Cellular Microenvironment
Disease Susceptibility
Hematologic Neoplasms
/ etiology
Hematopoiesis
Hematopoietic Stem Cells
/ cytology
Humans
Inflammation
/ etiology
Stem Cell Niche
bone marrow
hematopoietic stem cell
inflammation
myelopoiesis
niche
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
01
2020
accepted:
11
06
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
15
4
2021
Statut:
epublish
Résumé
Hematopoietic stem cells (HSC) reside in the bone marrow (BM) within a specialized micro-environment, the HSC niche, which comprises several cellular constituents. These include cells of mesenchymal origin, endothelial cells and HSC progeny, such as megakaryocytes and macrophages. The BM niche and its cell populations ensure the functional preservation of HSCs. During infection or systemic inflammation, HSCs adapt to and respond directly to inflammatory stimuli, such as pathogen-derived signals and elicited cytokines, in a process termed emergency myelopoiesis, which includes HSC activation, expansion, and enhanced myeloid differentiation. The cell populations of the niche participate in the regulation of emergency myelopoiesis, in part through secretion of paracrine factors in response to pro-inflammatory stimuli, thereby indirectly affecting HSC function. Here, we review the crosstalk between HSCs and cell populations in the BM niche, specifically focusing on the adaptation of the HSC niche to inflammation and how this inflammatory adaptation may, in turn, regulate emergency myelopoiesis.
Identifiants
pubmed: 32849521
doi: 10.3389/fimmu.2020.01540
pmc: PMC7396603
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1540Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE024716
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE028561
Pays : United States
Organisme : NIDCR NIH HHS
ID : R37 DE026152
Pays : United States
Informations de copyright
Copyright © 2020 Mitroulis, Kalafati, Bornhäuser, Hajishengallis and Chavakis.
Références
Nature. 2009 Apr 16;458(7240):904-8
pubmed: 19212321
Cell Rep. 2017 Mar 28;18(13):3204-3218
pubmed: 28355571
Blood. 2005 Nov 1;106(9):3020-7
pubmed: 16037394
Leukemia. 2019 Feb;33(2):536-541
pubmed: 30315231
Cell. 2018 Jan 11;172(1-2):147-161.e12
pubmed: 29328910
Science. 2016 Apr 22;352(6284):aaf1098
pubmed: 27102489
J Immunol. 2011 May 1;186(9):5367-75
pubmed: 21441445
J Clin Oncol. 2011 Jul 20;29(21):2897-903
pubmed: 21690473
Haematologica. 2017 Mar;102(3):445-453
pubmed: 27742772
Blood. 2014 Aug 28;124(9):1393-403
pubmed: 24990886
Immunity. 2015 Jan 20;42(1):159-71
pubmed: 25579427
Blood. 2009 Apr 30;113(18):4414-24
pubmed: 19179468
J Clin Invest. 2017 Oct 2;127(10):3624-3639
pubmed: 28846069
Cell Stem Cell. 2014 Jun 5;14(6):824-37
pubmed: 24704494
Trends Immunol. 2017 May;38(5):345-357
pubmed: 28216309
Nat Med. 2014 Nov;20(11):1315-20
pubmed: 25326802
Nature. 2019 May;569(7755):222-228
pubmed: 30971824
Nat Commun. 2018 Jun 22;9(1):2449
pubmed: 29934585
Nature. 2015 Oct 1;526(7571):126-30
pubmed: 26416744
Nature. 2018 May;557(7706):580-584
pubmed: 29769727
Cell. 2008 Dec 12;135(6):1118-29
pubmed: 19062086
Blood. 2010 Dec 2;116(23):4815-28
pubmed: 20713966
Nature. 2014 Aug 7;512(7512):78-81
pubmed: 25043017
Nature. 2013 Mar 14;495(7440):231-5
pubmed: 23434755
Nature. 2010 Aug 12;466(7308):829-34
pubmed: 20703299
Cell Rep. 2013 Sep 12;4(5):1022-34
pubmed: 24012753
Nat Cell Biol. 2016 Jun;18(6):607-18
pubmed: 27111842
Cell Rep. 2019 Dec 3;29(10):3313-3330.e4
pubmed: 31801092
Stem Cell Reports. 2016 Jun 14;6(6):940-956
pubmed: 27264973
Blood. 2003 Aug 15;102(4):1249-53
pubmed: 12714498
Nature. 2013 Oct 31;502(7473):637-43
pubmed: 24107994
Nature. 2016 Nov 10;539(7628):304-308
pubmed: 27783593
Cell Stem Cell. 2017 Jun 1;20(6):785-800.e8
pubmed: 28457748
J Immunol. 2012 Jun 15;188(12):5824-8
pubmed: 22586037
Crit Rev Oncol Hematol. 2016 Nov;107:90-99
pubmed: 27823655
Nat Immunol. 2019 Jul;20(7):802-811
pubmed: 31213716
Immunity. 2006 Jun;24(6):801-12
pubmed: 16782035
Cell Stem Cell. 2014 Apr 3;14(4):460-72
pubmed: 24561082
J Innate Immun. 2018;10(5-6):365-372
pubmed: 29874678
Thromb Haemost. 2018 Feb 07;:
pubmed: 29415284
Cancer Cell. 2011 Jul 12;20(1):11-24
pubmed: 21723200
J Clin Invest. 2013 Nov;123(11):4595-611
pubmed: 24216507
Immunity. 2018 Apr 17;48(4):632-648
pubmed: 29669248
Nature. 2013 May 9;497(7448):239-43
pubmed: 23575636
Cell Stem Cell. 2016 Nov 3;19(5):613-627
pubmed: 27666011
Nat Immunol. 2017 Sep;18(9):973-984
pubmed: 28671690
Nat Cell Biol. 2017 Mar;19(3):214-223
pubmed: 28218906
Exp Hematol. 2018 Mar;59:60-65
pubmed: 29195897
J Exp Med. 2017 Jul 3;214(7):2005-2021
pubmed: 28637883
Nature. 2008 Mar 27;452(7186):442-7
pubmed: 18256599
Cell Stem Cell. 2018 Jan 4;22(1):64-77.e6
pubmed: 29276143
Nat Med. 2014 Nov;20(11):1321-6
pubmed: 25326798
Nature. 2015 Apr 23;520(7548):549-52
pubmed: 25707806
Blood. 2005 Aug 15;106(4):1232-9
pubmed: 15845900
Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1908-13
pubmed: 9050878
Cell Stem Cell. 2014 Apr 3;14(4):445-459
pubmed: 24561084
Nat Immunol. 2012 Nov;13(11):1072-82
pubmed: 22983360
Haematologica. 2019 Oct;104(10):1928-1934
pubmed: 31515356
Int J Hematol. 2017 Feb;105(2):129-140
pubmed: 27943116
Cell Host Microbe. 2014 Jun 11;15(6):779-91
pubmed: 24882704
Nat Med. 2018 Jan;24(1):95-102
pubmed: 29155425
Nat Immunol. 2002 Jul;3(7):687-94
pubmed: 12068293
Cancers (Basel). 2018 Apr 03;10(4):
pubmed: 29614027
Cell Stem Cell. 2013 Sep 5;13(3):285-99
pubmed: 23850243
Cell Stem Cell. 2018 Dec 6;23(6):833-849.e5
pubmed: 30526882
Nature. 2012 Jan 25;481(7382):457-62
pubmed: 22281595
EMBO J. 2017 Aug 15;36(16):2390-2403
pubmed: 28673932
Blood. 2016 Dec 22;128(25):2960-2975
pubmed: 27737891
Blood. 2016 Jun 23;127(25):3175-9
pubmed: 27146433
Cell. 2006 Jan 27;124(2):407-21
pubmed: 16439213
Nat Med. 2014 Aug;20(8):833-46
pubmed: 25100529
Immunity. 2006 Dec;25(6):977-88
pubmed: 17174120
BMC Cancer. 2012 Jul 23;12:304
pubmed: 22823977
J Exp Med. 2011 Feb 14;208(2):261-71
pubmed: 21282381