Children From the Age of Three Show a Developmental Switch in T-Cell Differentiation.
Adenoids
/ immunology
Adolescent
Age Factors
Cell Differentiation
/ genetics
Child
Child, Preschool
Disease Susceptibility
Female
Humans
Immune System
/ cytology
Immunity, Cellular
/ genetics
Immunologic Memory
Lymphocyte Activation
/ genetics
Lymphocyte Count
Male
T-Lymphocyte Subsets
/ immunology
T-Lymphocytes
/ cytology
T-cell differentiation
adenoid
children
development
immune system
infant
multifunctional T-cells
pediatric immunology
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
24
03
2020
accepted:
18
06
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
20
4
2021
Statut:
epublish
Résumé
Every sixth child suffers from hypertrophy of the adenoid, a secondary lymphoid organ, at least once in childhood. Little is known about the impact of pathogen-provocation vs. developmental impact on T-cell responses after 1 year of age. Therefore, developmental and infection-driven influences on the formation of T-cell-compartments and -multifunctionality in adenoids were analyzed taking into account patient's history of age and inflammatory processes. Here, we show that in adenoids of 102 infants and children similar frequencies of naïve, effector, and memory T-cells were accumulated, whereby history of suffering from subsequent infection symptoms resulted in lower frequencies of CD4
Identifiants
pubmed: 32849561
doi: 10.3389/fimmu.2020.01640
pmc: PMC7402172
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1640Informations de copyright
Copyright © 2020 Knolle, Pierau, Hebel, Lampe, Jorch, Kropf, Arens and Brunner-Weinzierl.
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