The Role of Interleukin-6 and Inflammatory Cytokines in Pancreatic Cancer-Associated Depression.
depression
inflammatory cytokines
interleukin (il)-6
pancreatic cancer
paraneoplastic syndrome
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
23 Aug 2020
23 Aug 2020
Historique:
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
28
8
2020
Statut:
epublish
Résumé
Pancreatic cancer is historically known for representing a challenge for both diagnosis and treatment. Despite the advances in medicine, science, and technology, it remains the third leading cause of cancer-related deaths in the United States. The association between pancreatic cancer and major depression preceding the diagnosis is well known; however, it is still poorly understood, being considered an obscure piece of the puzzle the disease represents. It has been characterized as a paraneoplastic syndrome caused by the dysregulation of inflammatory cytokines, especially interleukin-6 (IL-6). Despite many types of studies describing the association, researchers have been reluctant to recommend it as a screening tool or early marker of the disease, mainly because of the non-specific nature of depression and anxiety in the studied patients. In this literature review, we aim to better understand the relationship between pancreatic cancer and major depression and characterize the immunologic mechanism of action behind the association.
Identifiants
pubmed: 32850269
doi: 10.7759/cureus.9969
pmc: PMC7444958
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e9969Informations de copyright
Copyright © 2020, Jarrin Jara et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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