Spontaneous and Radiation-Induced Chromosome Aberrations in Primary Fibroblasts of Patients With Pediatric First and Second Neoplasms.
childhood cancer
chromosome aberrations
ionizing radiation
radiation sensitivity
second primary malignancies
spontaneous chromosomal instability
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
19
11
2019
accepted:
26
06
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
28
8
2020
Statut:
epublish
Résumé
The purpose of the present study was to investigate whether former childhood cancer patients who developed a subsequent secondary primary neoplasm (SPN) are characterized by elevated spontaneous chromosomal instability or cellular and chromosomal radiation sensitivity as surrogate markers of compromised DNA repair compared to childhood cancer patients with a first primary neoplasm (FPN) only or tumor-free controls. Primary skin fibroblasts were obtained in a nested case-control study including 23 patients with a pediatric FPN, 22 matched patients with a pediatric FPN and an SPN, and 22 matched tumor-free donors. Clonogenic cell survival and cytogenetic aberrations in Giemsa-stained first metaphases were assessed after X-irradiation in G1 or on prematurely condensed chromosomes of cells irradiated and analyzed in G2. Fluorescence
Identifiants
pubmed: 32850427
doi: 10.3389/fonc.2020.01338
pmc: PMC7427586
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1338Informations de copyright
Copyright © 2020 Zahnreich, Poplawski, Hartel, Eckhard, Galetzka, Hankeln, Löbrich, Marron, Mirsch, Ritter, Scholz-Kreisel, Spix and Schmidberger.
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