Per2 Upregulation in Circulating Hematopoietic Progenitor Cells During Chronic HIV Infection.
HIV
Sirtuin 1
hematopoietic progenitor cells
period circadian clock 2
senescence
telomere length
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
11
2019
accepted:
11
06
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
22
6
2021
Statut:
epublish
Résumé
Chronic HIV infection accelerates immune aging and is associated with abnormal hemato-lymphopoiesis, but the relationship between HIV-induced aging and Hematopoietic Progenitor Cells (HPC) function is not well-defined. In the context of aging, it has been demonstrated using a murine model that Per2 (Period circadian clock 2) is a negative regulator of HPC survival and lineage potential. A possible involvement of Per2 modulation on hematopoietic failure during HIV infection has not yet been investigated. The aim of this study was to analyze whether Per2 is differently expressed and regulated on HPC during HIV infection, possibly providing a therapeutic target to restore lymphoid potential in the HPC compartment. To this purpose, Per2 expression in circulating HPC was compared in 69 chronic HIV infected patients under successful ART and in matched 30 uninfected healthy donors (HD). HPC aging was assessed by measuring relative telomere length (RTL), and HPC functionality was evaluated by Colony Forming Cell (CFC) assay from both
Identifiants
pubmed: 32850472
doi: 10.3389/fcimb.2020.00362
pmc: PMC7396677
doi:
Substances chimiques
PER2 protein, human
0
Per2 protein, mouse
0
Period Circadian Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
362Informations de copyright
Copyright © 2020 Bordoni, Tartaglia, Refolo, Sacchi, Grassi, Antinori, Fimia and Agrati.
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