Optimization of a Soft Ensemble Vote Classifier for the Prediction of Chimeric Virus-Like Particle Solubility and Other Biophysical Properties.
hydrophobicity scales
machine learning
optimization
precipitation
solubility
virus-like particles
Journal
Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513
Informations de publication
Date de publication:
2020
2020
Historique:
received:
11
05
2020
accepted:
09
07
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
28
8
2020
Statut:
epublish
Résumé
Chimeric virus-like particles (cVLPs) are protein-based nanostructures applied as investigational vaccines against infectious diseases, cancer, and immunological disorders. Low solubility of cVLP vaccine candidates is a challenge that can prevent development of these very substances. Solubility of cVLPs is typically assessed empirically, leading to high time and material requirements. Prediction of cVLP solubility
Identifiants
pubmed: 32850736
doi: 10.3389/fbioe.2020.00881
pmc: PMC7411134
doi:
Types de publication
Journal Article
Langues
eng
Pagination
881Informations de copyright
Copyright © 2020 Vormittag, Klamp and Hubbuch.
Références
Front Bioeng Biotechnol. 2020 May 05;8:395
pubmed: 32432098
Curr Opin Virol. 2016 Jun;18:44-9
pubmed: 27039982
J Biol Chem. 1971 Apr 10;246(7):2211-7
pubmed: 5555568
BMC Biotechnol. 2017 Nov 10;17(1):79
pubmed: 29126399
Sci Rep. 2015 Jun 26;5:11639
pubmed: 26113394
Bioinformatics. 2017 Oct 1;33(19):3098-3100
pubmed: 28575391
J Virol. 2005 Nov;79(21):13656-66
pubmed: 16227285
Methods Mol Biol. 2010;614:111-24
pubmed: 20225039
Biotechnol Bioeng. 2019 Jun;116(6):1366-1379
pubmed: 30684365
Cancer Res. 2011 Jan 15;71(2):516-27
pubmed: 21224362
Biochemistry. 2009 Mar 3;48(8):1736-42
pubmed: 19196007
Front Bioeng Biotechnol. 2020 May 25;8:489
pubmed: 32671023
Nucleic Acids Res. 2008 Jan;36(Database issue):D202-5
pubmed: 17998252
Eur J Biochem. 1979 Jun;97(1):175-81
pubmed: 477664
Bioinformatics. 2005 Jun 1;21(11):2651-6
pubmed: 15797910
J Virol. 1993 Oct;67(10):6064-70
pubmed: 8396669
Bioinformatics. 2007 Oct 1;23(19):2536-42
pubmed: 17150993
Curr Opin Chem Biol. 2016 Jun;32:34-47
pubmed: 26994695
Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16998-7003
pubmed: 21949376
Nature. 1984 Jan 12-18;307(5947):178-80
pubmed: 6318124
J Mol Biol. 2012 Oct 12;423(1):63-78
pubmed: 22750730
Bioinformatics. 2006 Feb 1;22(3):278-84
pubmed: 16332713
J Mol Biol. 1982 May 5;157(1):105-32
pubmed: 7108955
Mol Cell. 1999 Jun;3(6):771-80
pubmed: 10394365
Amino Acids. 2000;18(4):329-37
pubmed: 10949916
BMC Bioinformatics. 2013 Oct 28;14:314
pubmed: 24165390
Bioinformatics. 2009 Sep 1;25(17):2200-7
pubmed: 19549632
Int J Pharm. 2019 May 30;563:337-346
pubmed: 30935914
Annu Rev Biophys Biophys Chem. 1986;15:321-53
pubmed: 3521657
Expert Rev Vaccines. 2009 Nov;8(11):1565-73
pubmed: 19863249
Biol Res. 2016 Jul 04;49(1):31
pubmed: 27378087