Mechanism of Activation of Mechanistic Target of Rapamycin Complex 1 by Methionine.
S-adenosyl methionine
SAMTOR
autophagy
mechanistic target of rapamycin complex 1
methionine
phosphatase 2A methylation
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
05
2020
accepted:
13
07
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
28
8
2020
Statut:
epublish
Résumé
Nutrients are closely involved in the regulation of lifespan and metabolic health. Cellular activities, such as the regulation of metabolism, growth, and aging, are mediated by a network of nutrients and nutrient-sensing pathways. Among the nutrient-sensing pathways, the mechanistic target of rapamycin complex 1 (mTORC1) acts as the central regulator of cellular functions, which include autophagy. Autophagy plays a significant role in the removal of protein aggregates and damaged or excess organelles, including mitochondria, to maintain intracellular homeostasis, which is involved in lifespan extension and cardiometabolic health. Moreover, dietary methionine restriction may have a beneficial effect on lifespan extension and metabolic health. In contrast, methionine may activate mTORC1 and suppress autophagy. As the mechanism of methionine sensing on mTORC1, SAMTOR was identified as a sensor of
Identifiants
pubmed: 32850834
doi: 10.3389/fcell.2020.00715
pmc: PMC7431653
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
715Informations de copyright
Copyright © 2020 Kitada, Xu, Ogura, Monno and Koya.
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