Extracellular Vesicles as Mediators of Cellular Cross Talk in the Lung Microenvironment.
asthma
chronic obstructive pulmonary disease
exosomes
extracellular vesicles
microRNA
sarcoidosis
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2020
2020
Historique:
received:
17
02
2020
accepted:
03
06
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
28
8
2020
Statut:
epublish
Résumé
The human lung is a complex tissue subdivided into several regions that differ in size, function, and resident cell types. Despite years of intensive research, we still do not fully understand the cross talk between these different regions and diverse cell populations in the lung and how this is altered in the development of chronic respiratory disease. The discovery of extracellular vesicles (EVs), small membrane vesicles released from cells for intercellular communication, has added another layer of complexity to cellular cross talk in the complex lung microenvironment. EVs from patients with chronic obstructive pulmonary disease, asthma, or sarcoidosis have been shown to carry microRNAs, proteins, and lipids that may contribute to inflammation or tissue degeneration. Here, we summarize the contribution of these small vesicles in the interplay of several different cell types in the lung microenvironment, with a focus on the development of chronic respiratory diseases. Although there are already many studies demonstrating the adverse effects of EVs in the diseased lung, we still have substantial knowledge gaps regarding the concrete role of EV involvement in lung disease, which should be addressed in future studies.
Identifiants
pubmed: 32850874
doi: 10.3389/fmed.2020.00326
pmc: PMC7417309
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
326Subventions
Organisme : NIEHS NIH HHS
ID : P42 ES027723
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029981
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128502
Pays : United States
Informations de copyright
Copyright © 2020 Bartel, Deshane, Wilkinson and Gabrielsson.
Références
Eur Respir J. 2017 May 25;49(5):
pubmed: 28546273
Allergy. 2020 Feb;75(2):346-356
pubmed: 31386204
Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E968-77
pubmed: 26858453
Eur Respir Rev. 2017 Jun 28;26(144):
pubmed: 28659497
J Extracell Vesicles. 2015 May 14;4:27066
pubmed: 25979354
J Extracell Vesicles. 2018 Nov 23;7(1):1535750
pubmed: 30637094
Am J Respir Cell Mol Biol. 2015 Jun;52(6):772-84
pubmed: 25360868
Nat Nanotechnol. 2020 Mar;15(3):217-223
pubmed: 32066904
J Allergy Clin Immunol. 2013 Mar;131(3):894-903
pubmed: 23333113
J Allergy Clin Immunol. 2013 Apr;131(4):1194-203, 1203.e1-14
pubmed: 23414598
Int J Chron Obstruct Pulmon Dis. 2015 Dec 22;11:31-41
pubmed: 26730186
J Clin Invest. 2007 Nov;117(11):3576-82
pubmed: 17975675
Nat Commun. 2015 Oct 07;6:8472
pubmed: 26442449
PLoS One. 2016 Nov 29;11(11):e0167250
pubmed: 27898728
Immunity. 2015 Jul 21;43(1):29-40
pubmed: 26200011
Am J Respir Crit Care Med. 2018 Dec 15;198(12):1527-1538
pubmed: 30044642
Am J Respir Crit Care Med. 2020 Jan 1;201(1):83-94
pubmed: 31461630
J Allergy Clin Immunol. 2014 Sep;134(3):499-507
pubmed: 25171864
Allergy. 2018 Jan;73(1):178-186
pubmed: 28649804
Allergy. 2015 Dec;70(12):1651-5
pubmed: 26198793
Respir Res. 2018 Feb 20;19(1):31
pubmed: 29458372
J Extracell Vesicles. 2017 Mar 7;6(1):1286095
pubmed: 28326170
FASEB J. 2009 Jun;23(6):1858-68
pubmed: 19190083
Proc Am Thorac Soc. 2008 Sep 15;5(7):763-6
pubmed: 18757314
Am J Respir Cell Mol Biol. 2004 Jul;31(1):22-7
pubmed: 14962974
FASEB J. 2020 Mar;34(3):4718-4731
pubmed: 32030817
Am J Physiol Lung Cell Mol Physiol. 2014 Aug 15;307(4):L326-37
pubmed: 24973403
J Allergy Clin Immunol. 2015 Feb;135(2):413-424.e15
pubmed: 25420684
Cell. 2019 Jan 10;176(1-2):113-126.e15
pubmed: 30633902
J Leukoc Biol. 2017 May;101(5):1191-1199
pubmed: 28096299
Semin Cell Dev Biol. 2017 Jul;67:48-55
pubmed: 28104520
J Clin Invest. 1985 May;75(5):1488-95
pubmed: 3923038
Am J Pathol. 2013 May;182(5):1552-62
pubmed: 23499464
Redox Biol. 2018 Sep;18:54-64
pubmed: 29986209
Nat Med. 2012 May 04;18(5):716-25
pubmed: 22561835
J Allergy Clin Immunol. 2007 Dec;120(6):1418-24
pubmed: 17868797
Lancet. 2003 Sep 27;362(9389):1053-61
pubmed: 14522537
Blood. 2013 Feb 7;121(6):984-95
pubmed: 23144169
Blood. 2007 Nov 1;110(9):3234-44
pubmed: 17666571
J Extracell Vesicles. 2015 Nov 11;4:28388
pubmed: 26563733
Eur Respir J. 2018 Oct 4;52(4):
pubmed: 30190268
J Cell Biol. 2013 Feb 18;200(4):373-83
pubmed: 23420871
Thorax. 2020 Jun;75(6):449-458
pubmed: 32265339
Eur Respir J. 2015 Apr;45(4):1150-62
pubmed: 25700381
Respir Res. 2016 Jul 26;17(1):92
pubmed: 27460105
Front Immunol. 2019 Aug 21;10:1987
pubmed: 31497021
Thorax. 2016 Feb;71(2):126-32
pubmed: 26645414
Eur Respir J. 2016 Aug;48(2):359-69
pubmed: 27418555
Respirology. 2018 Dec;23(12):1166-1172
pubmed: 29956871
J Immunol. 2009 Apr 15;182(8):5052-62
pubmed: 19342685
Thorax. 2016 Nov;71(11):1020-1029
pubmed: 27287089
Pathobiology. 2019;86(2-3):111-117
pubmed: 30408778
Cell Rep. 2019 Jan 22;26(4):933-944.e4
pubmed: 30673615
Nat Cell Biol. 2007 Jun;9(6):654-9
pubmed: 17486113
Nat Cell Biol. 2019 Jan;21(1):9-17
pubmed: 30602770
J Exp Med. 2015 May 4;212(5):729-42
pubmed: 25847945
Immunity. 2009 Sep 18;31(3):412-24
pubmed: 19766084
Proc Am Thorac Soc. 2009 Dec;6(8):683-92
pubmed: 20008876
Am J Respir Cell Mol Biol. 2019 Mar;60(3):269-278
pubmed: 30265126
J Allergy Clin Immunol. 2017 Apr;139(4):1186-1194
pubmed: 27566455
J Exp Med. 1996 Mar 1;183(3):1161-72
pubmed: 8642258
Environ Pollut. 2019 Nov;254(Pt A):112933
pubmed: 31382213
J Extracell Vesicles. 2013 May 27;2:
pubmed: 24009894
J Allergy Clin Immunol. 2010 Nov;126(5):1032-40, 1040.e1-4
pubmed: 20728205
Allergy. 2012 Jul;67(7):911-9
pubmed: 22620679
Thorax. 2010 Nov;65(11):1016-24
pubmed: 20880880
Clin Exp Allergy. 2018 Sep;48(9):1173-1185
pubmed: 29451337
Eur Respir J. 2003 Oct;22(4):578-83
pubmed: 14582906
Am J Respir Crit Care Med. 2017 Nov 15;196(10):1275-1286
pubmed: 28598224