The Potential Innovative Use of Bacteriophages Within the DAC
bacteriophage
hydrogel
megaprosthesis
phage therapy
prosthetic joint infection
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2020
2020
Historique:
received:
08
04
2020
accepted:
09
06
2020
entrez:
28
8
2020
pubmed:
28
8
2020
medline:
28
8
2020
Statut:
epublish
Résumé
Infection is the most dramatic complication in patients with knee megaprosthesis. Its management is more complex in comparison with patients with primary arthroplasty, with a high risk of relapse. Lytic bacteriophages are considered to have a high potential in patients with prosthetic joint infection as it has been demonstrated that they have a synergistic anti-biofilm activity with antibiotics. The Defensive Antibacterial Coating (DAC®) hydrogel is a hydrogel available in the market that has been designed to prevent the adherence of bacteria on a prosthetic joint and to have the ability to transport and release anti-bacterial substances such as antibiotics. We report here the case of a patient with a catastrophic relapsing
Identifiants
pubmed: 32850878
doi: 10.3389/fmed.2020.00342
pmc: PMC7410981
doi:
Types de publication
Case Reports
Langues
eng
Pagination
342Informations de copyright
Copyright © 2020 Ferry, Batailler, Petitjean, Chateau, Fevre, Forestier, Brosset, Leboucher, Kolenda, Laurent and Lustig.
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