Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer.

Case-Control Studies Cholesterol, HDL / blood Cholesterol, LDL / blood Endometrial Neoplasms / blood Female Genome-Wide Association Study Humans Mendelian Randomization Analysis Risk Triglycerides / blood
HDL cholesterol LDL cholesterol Mendelian randomization endometrial cancer risk triglycerides

Journal

International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124

Informations de publication

Date de publication:
15 01 2021
Historique:
received: 03 12 2019
revised: 08 05 2020
accepted: 26 05 2020
pubmed: 28 8 2020
medline: 9 6 2021
entrez: 28 8 2020
Statut: ppublish

Résumé

Blood lipids have been associated with the development of a range of cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies have reported inconsistent associations between blood lipids and cancer risk. To reduce biases from unmeasured confounding, we performed a bidirectional, two-sample Mendelian randomization analysis to investigate the relationship between levels of three blood lipids (low-density lipoprotein [LDL] and high-density lipoprotein [HDL] cholesterol, and triglycerides) and endometrial cancer risk. Genetic variants associated with each of these blood lipid levels (P < 5 × 10

Identifiants

DOI: 10.1002/ijc.33206 PMID: 32851660 PMC: PMC7757859
pubmed: 32851660
doi: 10.1002/ijc.33206
pmc: PMC7757859
mid: NIHMS1653263
doi:

Substances chimiques

Cholesterol, HDL 0
Cholesterol, LDL 0
Triglycerides 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

307-319

Subventions

Organisme : Canadian Institutes of Health Research (CIHR)
ID : MOP-86727
Organisme : NCI NIH HHS
ID : K05 CA092002
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA087969
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA058598
Pays : United States
Organisme : US National Institutes of Health
ID : CA1X01HG007491-01
Organisme : NCI NIH HHS
ID : R01 CA105212
Pays : United States
Organisme : NIA NIH HHS
ID : HHSN271201100004C
Pays : United States
Organisme : NIH Grant
ID : R01 CA91019
Organisme : the National Institutes of Health
ID : CA128978
Organisme : NHLBI NIH HHS
ID : HHSN268201100001I
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA096400
Pays : United States
Organisme : Cancer Research UK
ID : C12292/A11174
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 100069
Pays : United Kingdom
Organisme : NIH Grant
ID : RO1 CA 87538
Organisme : NCI NIH HHS
ID : R01 CA108634
Pays : United States
Organisme : Cancer Research UK
ID : C5047/A15007
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA087538
Pays : United States
Organisme : Cancer UK Grant
ID : C1287/A16563
Organisme : NCI NIH HHS
ID : R01 CA091019
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA134958
Pays : United States
Organisme : Cancer Research UK
ID : 29186
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : HHSN268201100004I
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA128008
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100046C
Pays : United States
Organisme : Cancer Research UK
ID : C1281/A12014
Pays : United Kingdom
Organisme : NIH Grant
ID : NO1 HD23166
Organisme : NIH Grant
ID : R35 CA39779
Organisme : Cancer Research UK
ID : C5047/A10692
Pays : United Kingdom
Organisme : WHI NIH HHS
ID : HHSN268201100003C
Pays : United States
Organisme : US National Institutes of Health
ID : R01-CA149429
Organisme : NCI NIH HHS
ID : R01 CA082838
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : US National Institutes of Health
ID : U19-CA148112
Organisme : NCI NIH HHS
ID : R01 CA128978
Pays : United States
Organisme : Wellcome Trust
ID : 090532/Z/09Z
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C1287/A10118
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U19 CA148537
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA148065-01
Pays : United States
Organisme : NCI NIH HHS
ID : K05 CA136967
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA074847
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA186107
Pays : United States
Organisme : WHI NIH HHS
ID : HHSN268201100002C
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA122443
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA015083
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA080636
Pays : United States
Organisme : Cancer Research UK
ID : C8197/A16565
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA098346
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA077398
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA054281
Pays : United States
Organisme : NIH HHS
ID : CA128978
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA148112
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA149429
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA017054
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA148065
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : HHSN268201100003I
Pays : United States
Organisme : NIH Grant
ID : R01 CA77398
Organisme : NHLBI NIH HHS
ID : HHSN268201100002I
Pays : United States
Organisme : Wellcome Trust
ID : 085475
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA049449
Pays : United States
Organisme : National Cancer Institute of United States Public Health Service
ID : P30 CA15083
Organisme : NIH Grant
ID : 2R01 CA082838
Organisme : NICHD NIH HHS
ID : N01 HD023166
Pays : United States
Organisme : Cancer Research UK
ID : C490/A10124
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C1287/A10710
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C5047/A8384
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R37 CA054281
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA136393
Pays : United States
Organisme : NIH Grant
ID : RO3 CA80636
Organisme : NIH Grant
ID : R01 CA49449
Organisme : WHI NIH HHS
ID : HHSN268201100001C
Pays : United States
Organisme : WHI NIH HHS
ID : HHSN268201100004C
Pays : United States
Organisme : Post-Cancer GWAS initiative
ID : 1U19 CA148065
Organisme : Wellcome Trust
ID : 209057
Pays : United Kingdom
Organisme : Post-Cancer GWAS initiative
ID : 1U19 CA148537
Organisme : NIH Grant
ID : RO1 CA75977
Organisme : Wellcome Trust
ID : 068545/Z/02
Pays : United Kingdom
Organisme : NIH Grant
ID : CA54281

Informations de copyright

© 2020 Union for International Cancer Control.

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Auteurs

Pik-Fang Kho (PF)

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
School of Biomedical Science, Queensland University of Technology, Brisbane, Queensland, Australia.

Frederic Amant (F)

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals KU Leuven, University of Leuven, Leuven, Belgium.

Daniela Annibali (D)

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals KU Leuven, University of Leuven, Leuven, Belgium.

Katie Ashton (K)

Hunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.
Centre for Information Based Medicine, University of Newcastle, Callaghan, New South Wales, Australia.
Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Callaghan, New South Wales, Australia.

John Attia (J)

Hunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.
Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.

Paul L Auer (PL)

Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.

Matthias W Beckmann (MW)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.

Amanda Black (A)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

Louise Brinton (L)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

Daniel D Buchanan (DD)

Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia.
University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, Victoria, Australia.
ORCID: 0000-0003-2225-6675

Stephen J Chanock (SJ)

Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Chu Chen (C)

Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
ORCID: 0000-0003-2267-8050

Maxine M Chen (MM)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Timothy H T Cheng (THT)

Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.

Linda S Cook (LS)

University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, Alberta, Canada.

Marta Crous-Bous (M)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Kamila Czene (K)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Immaculata De Vivo (I)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
ORCID: 0000-0002-7185-7402

Joe Dennis (J)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Thilo Dörk (T)

Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
ORCID: 0000-0002-9458-0282

Sean C Dowdy (SC)

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mayo Clinic, Rochester, Minnesota, USA.

Alison M Dunning (AM)

Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

Matthias Dürst (M)

Department of Gynaecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany.

Douglas F Easton (DF)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

Arif B Ekici (AB)

Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.

Peter A Fasching (PA)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California, USA.
ORCID: 0000-0003-4885-8471

Brooke L Fridley (BL)

Department of Biostatistics, Kansas University Medical Center, Kansas City, Kansas, USA.

Christine M Friedenreich (CM)

Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, Alberta, Canada.
ORCID: 0000-0002-4783-1966

Montserrat García-Closas (M)

Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Mia M Gaudet (MM)

Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia, USA.
ORCID: 0000-0002-6429-4007

Graham G Giles (GG)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.

Ellen L Goode (EL)

Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA.
ORCID: 0000-0002-9094-8326

Maggie Gorman (M)

Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.

Christopher A Haiman (CA)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Per Hall (P)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Oncology, Södersjukhuset, Stockholm, Sweden.

Susan E Hankinson (SE)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Department of Biostatistics & Epidemiology, University of Massachusetts, Amherst, Amherst, Massachusetts, USA.

Alexander Hein (A)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.

Peter Hillemanns (P)

Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.

Shirley Hodgson (S)

Department of Clinical Genetics, St George's, University of London, London, UK.

Erling A Hoivik (EA)

Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.

Elizabeth G Holliday (EG)

Hunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.
Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.

David J Hunter (DJ)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Angela Jones (A)

Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.

Peter Kraft (P)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Camilla Krakstad (C)

Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.

Diether Lambrechts (D)

VIB Center for Cancer Biology, Leuven, Belgium.
Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, Belgium.

Loic Le Marchand (L)

Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.

Xiaolin Liang (X)

Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

Annika Lindblom (A)

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.

Jolanta Lissowska (J)

Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center, Oncology Institute, Warsaw, Poland.

Jirong Long (J)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Lingeng Lu (L)

Chronic Disease Epidemiology, Yale School of Medicine, New Haven, Connecticut, USA.
ORCID: 0000-0001-9871-0809

Anthony M Magliocco (AM)

Department of Anatomic Pathology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.

Lynn Martin (L)

Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.

Mark McEvoy (M)

Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.

Roger L Milne (RL)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.

Miriam Mints (M)

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Rami Nassir (R)

Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, USA.

Geoffrey Otton (G)

School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.

Claire Palles (C)

Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.

Loreall Pooler (L)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Tony Proietto (T)

School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.

Timothy R Rebbeck (TR)

Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

Stefan P Renner (SP)

Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.

Harvey A Risch (HA)

Chronic Disease Epidemiology, Yale School of Medicine, New Haven, Connecticut, USA.

Matthias Rübner (M)

Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.

Ingo Runnebaum (I)

Department of Gynaecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany.

Carlotta Sacerdote (C)

Center for Cancer Prevention (CPO-Peimonte), Turin, Italy.
Human Genetics Foundation (HuGeF), Turin, Italy.
ORCID: 0000-0002-8008-5096

Gloria E Sarto (GE)

Department of Obstetrics and Gynecology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.

Fredrick Schumacher (F)

Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.

Rodney J Scott (RJ)

Hunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.
Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Callaghan, New South Wales, Australia.
Division of Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, New South Wales, Australia.

V Wendy Setiawan (VW)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Mitul Shah (M)

Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

Xin Sheng (X)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Xiao-Ou Shu (XO)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
ORCID: 0000-0002-0711-8314

Melissa C Southey (MC)

Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia.
Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.

Emma Tham (E)

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Clinical Genetics, Karolinska Institutet, Stockholm, Sweden.

Ian Tomlinson (I)

Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.

Jone Trovik (J)

Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.

Constance Turman (C)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Jonathan P Tyrer (JP)

Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

David Van Den Berg (D)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Zhaoming Wang (Z)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
ORCID: 0000-0001-7556-3869

Nicolas Wentzensen (N)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
ORCID: 0000-0003-1251-0836

Lucy Xia (L)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Yong-Bing Xiang (YB)

State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
ORCID: 0000-0002-3840-9915

Hannah P Yang (HP)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

Herbert Yu (H)

Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
ORCID: 0000-0003-3950-4815

Wei Zheng (W)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Penelope M Webb (PM)

Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Deborah J Thompson (DJ)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Amanda B Spurdle (AB)

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID: 0000-0003-1337-7897

Dylan M Glubb (DM)

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Tracy A O'Mara (TA)

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID: 0000-0002-5436-3232

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Mendelian randomization analyses suggest a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Lipoprotéines HDL › Cholestérol HDL › Mendelian randomization analyses suggest a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Lipoprotéines LDL › Cholestérol LDL › Mendelian randomization analyses suggest a...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital féminin › Tumeurs de l'utérus › Tumeurs de l'endomètre › Mendelian randomization analyses suggest a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Mendelian randomization analyses suggest a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mendelian randomization analyses suggest a...
questionsmedicales.fr › Techniques d'investigation › Analyse de randomisation mendélienne › Mendelian randomization analyses suggest a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Mendelian randomization analyses suggest a...
questionsmedicales.fr › Lipides › Glycérides › Triglycéride › Mendelian randomization analyses suggest a...