Ketogenic diet, neuroprotection, and antiepileptogenesis.
Antiepileptogenesis
Epigenetics
Epilepsy
Ketogenic diet
Neuroprotection
Journal
Epilepsy research
ISSN: 1872-6844
Titre abrégé: Epilepsy Res
Pays: Netherlands
ID NLM: 8703089
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
29
04
2020
revised:
30
06
2020
accepted:
13
08
2020
pubmed:
28
8
2020
medline:
12
10
2021
entrez:
28
8
2020
Statut:
ppublish
Résumé
High fat, low carbohydrate ketogenic diets (KD) have been in use for the treatment of epilepsy for almost a hundred years. Remarkably, seizures that are resistant to conventional anti-seizure drugs can in many cases be controlled by the KD therapy, and it has been shown that many patients with epilepsy become seizure free even after discontinuation of the diet. These findings suggest that KD combine anti-seizure effects with disease modifying effects. In addition to the treatment of epilepsy, KDs are now widely used for the treatment of a wide range of conditions including weight reduction, diabetes, and cancer. The reason for the success of metabolic therapies is based on the synergism of at least a dozen different mechanisms through which KDs provide beneficial activities. Among the newest findings are epigenetic mechanisms (DNA methylation and histone acetylation) through which KD exerts long-lasting disease modifying effects. Here we review mechanisms through which KD can affect neuroprotection in the brain, and how a combination of those mechanisms with epigenetic alterations can attenuate and possibly reverse the development of epilepsy.
Identifiants
pubmed: 32854046
pii: S0920-1211(20)30494-0
doi: 10.1016/j.eplepsyres.2020.106444
pmc: PMC7655615
mid: NIHMS1623729
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
106444Subventions
Organisme : NINDS NIH HHS
ID : R01 NS065957
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS103740
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
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