Multiple environmental exposures in early-life and allergy-related outcomes in childhood.
Allergic disease
Childhood
Environmental exposure
Exposome
Pregnancy
Journal
Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
05
03
2020
revised:
10
06
2020
accepted:
03
08
2020
pubmed:
28
8
2020
medline:
12
1
2021
entrez:
28
8
2020
Statut:
ppublish
Résumé
Early onset and high prevalence of allergic diseases result in high individual and socio-economic burdens. Several studies provide evidence for possible effects of environmental factors on allergic diseases, but these are mainly single-exposure studies. The exposome provides a novel holistic approach by simultaneously studying a large set of exposures. The aim of the study was to evaluate the association between a broad range of prenatal and childhood environmental exposures and allergy-related outcomes in children. Analyses of associations between 90 prenatal and 107 childhood exposures and allergy-related outcomes (last 12 months: rhinitis and itchy rash; ever: doctor-diagnosed eczema and food allergy) in 6-11 years old children (n = 1270) from the European Human Early-Life Exposome cohort were performed. Initially, we used an exposome-wide association study (ExWAS) considering the exposures independently, followed by a deletion-substitution-addition selection (DSA) algorithm considering all exposures simultaneously. All the exposure variables selected in the DSA were included in a final multi-exposure model using binomial general linear model (GLM). In ExWAS, no exposures were associated with the outcomes after correction for multiple comparison. In multi-exposure models for prenatal exposures, lower distance of residence to nearest road and higher di-iso-nonyl phthalate level were associated with increased risk of rhinitis, and particulate matter absorbance (PM This first comprehensive and systematic analysis of many environmental exposures suggests that prenatal exposure to traffic-related variables, PM
Identifiants
pubmed: 32854059
pii: S0160-4120(20)31993-0
doi: 10.1016/j.envint.2020.106038
pmc: PMC8768577
mid: NIHMS1759230
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106038Subventions
Organisme : Medical Research Council
ID : MR/S037527/1
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : P30 ES007048
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.
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