Effect of change in cell substrate on the critical quality attributes of L-Zagreb Mumps vaccine manufactured using parallel plate bioreactor.
CQA
L-Zagreb
MRC-5 cells
Mumps
Parallel Plate Bioreactor
Vero cells
Journal
Biologicals : journal of the International Association of Biological Standardization
ISSN: 1095-8320
Titre abrégé: Biologicals
Pays: England
ID NLM: 9004494
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
24
06
2020
revised:
10
07
2020
accepted:
29
07
2020
pubmed:
29
8
2020
medline:
10
8
2021
entrez:
29
8
2020
Statut:
ppublish
Résumé
Leningrad-Zagreb strain of mumps vaccine virus was grown on two different cell substrates viz. MRC-5 cells and Vero cells besides its original cell substrate i.e. Chicken Embryo Cells. Homogeneous virus pools prepared from each set of experiments were then lyophilized as per standard in-house protocol. Critical Quality Attributes (CQAs) such as the titer of the bulk vaccine and potency and stability of the lyophilized vaccine were then estimated using the CCID
Identifiants
pubmed: 32855039
pii: S1045-1056(20)30088-9
doi: 10.1016/j.biologicals.2020.07.008
pii:
doi:
Substances chimiques
Mumps Vaccine
0
Vaccines, Attenuated
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
29-37Informations de copyright
Copyright © 2020 International Alliance for Biological Standardization. Published by Elsevier Ltd. All rights reserved.