Glycosylation-dependent opsonophagocytic activity of staphylococcal protein A antibodies.


Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
15 09 2020
Historique:
pubmed: 29 8 2020
medline: 27 10 2020
entrez: 29 8 2020
Statut: ppublish

Résumé

Antibodies may bind to bacterial pathogens or their toxins to control infections, and their effector activity is mediated through the recruitment of complement component C1q or the engagement with Fcγ receptors (FcγRs). For bacterial pathogens that rely on a single toxin to cause disease, immunity correlates with toxin neutralization. Most other bacterial pathogens, including

Identifiants

pubmed: 32855300
pii: 2003621117
doi: 10.1073/pnas.2003621117
pmc: PMC7502815
doi:

Substances chimiques

Antibodies, Bacterial 0
Antibodies, Monoclonal 0
Staphylococcal Protein A 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

22992-23000

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI052474
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI148543
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI155716
Pays : United States

Informations de copyright

Copyright © 2020 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

Competing interest statement: D.M. declares a competing financial interest as the inventor of patents describing therapeutic antibodies against S. aureus.

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Auteurs

Xinhai Chen (X)

Howard Taylor Ricketts Laboratory, Argonne National Laboratory, Lemont, IL 60439.
Department of Microbiology, The University of Chicago, Chicago, IL 60637.

Miaomiao Shi (M)

Howard Taylor Ricketts Laboratory, Argonne National Laboratory, Lemont, IL 60439.
Department of Microbiology, The University of Chicago, Chicago, IL 60637.

Xin Tong (X)

Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742.

Hwan Keun Kim (HK)

Howard Taylor Ricketts Laboratory, Argonne National Laboratory, Lemont, IL 60439.
Department of Microbiology, The University of Chicago, Chicago, IL 60637.

Lai-Xi Wang (LX)

Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742.

Olaf Schneewind (O)

Howard Taylor Ricketts Laboratory, Argonne National Laboratory, Lemont, IL 60439.
Department of Microbiology, The University of Chicago, Chicago, IL 60637.

Dominique Missiakas (D)

Howard Taylor Ricketts Laboratory, Argonne National Laboratory, Lemont, IL 60439; dmissiak@bsd.uchicago.edu.
Department of Microbiology, The University of Chicago, Chicago, IL 60637.

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