Zika virus infection enhances future risk of severe dengue disease.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
28 08 2020
28 08 2020
Historique:
received:
08
04
2020
accepted:
16
07
2020
entrez:
29
8
2020
pubmed:
29
8
2020
medline:
26
9
2020
Statut:
ppublish
Résumé
The Zika pandemic sparked intense interest in whether immune interactions among dengue virus serotypes 1 to 4 (DENV1 to -4) extend to the closely related Zika virus (ZIKV). We investigated prospective pediatric cohorts in Nicaragua that experienced sequential DENV1 to -3 (2004 to 2015), Zika (2016 to 2017), and DENV2 (2018 to 2020) epidemics. Risk of symptomatic DENV2 infection and severe disease was elevated by one prior ZIKV infection, one prior DENV infection, or one prior DENV infection followed by one ZIKV infection, compared with being flavivirus-naïve. By contrast, multiple prior DENV infections reduced dengue risk. Further, although high preexisting anti-DENV antibody titers protected against DENV1, DENV3, and ZIKV disease, intermediate titers induced by previous ZIKV or DENV infection enhanced future risk of DENV2 disease and severity, as well as DENV3 severity. The observation that prior ZIKV infection can modulate dengue disease severity like a DENV serotype poses challenges to development of dengue and Zika vaccines.
Identifiants
pubmed: 32855339
pii: 369/6507/1123
doi: 10.1126/science.abb6143
pmc: PMC8274975
mid: NIHMS1692374
doi:
Substances chimiques
Antibodies, Viral
0
Dengue Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1123-1128Subventions
Organisme : FIC NIH HHS
ID : D43 TW010540
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI106695
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI118610
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI099631
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI107731
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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