Pathological features and outcomes of incidental renal cell carcinoma in candidate solid organ donors.
Cancer transmission
Donor evaluation
Kidney transplantation
Renal cell carcinoma
Risk assessment
Journal
Kidney research and clinical practice
ISSN: 2211-9132
Titre abrégé: Kidney Res Clin Pract
Pays: Korea (South)
ID NLM: 101586778
Informations de publication
Date de publication:
31 Dec 2020
31 Dec 2020
Historique:
received:
06
04
2020
revised:
09
07
2020
accepted:
13
07
2020
pubmed:
29
8
2020
medline:
29
8
2020
entrez:
29
8
2020
Statut:
ppublish
Résumé
We report the findings of a single Italian center in the evaluation of renal lesions in deceased donors from 2001 to 2017. In risk evaluation, we applied the current Italian guidelines, which include donors with small (< 4 cm, stage pT1a) renal carcinomas in the category of non-standard donors with a negligible risk of cancer transmission. From the revision of our registries, 2,406 donors were considered in the Emilia Romagna region of Italy; organs were accepted from 1,321 individuals for a total of 3,406 organs. The evaluation of donor safety required frozen section analysis for 51 donors, in which a renal suspicious lesion was detected by ultrasound. Thirty-two primary renal tumors were finally diagnosed: 26 identified by frozen sections and 6 in discarded kidneys. The 32 tumors included 13 clear cell renal cell carcinomas (RCCs), 6 papillary RCCs, 6 angiomyolipomas, 5 oncocytomas, 1 chromophobe RCC, and 1 papillary adenoma. No cases of tumor transmission were recorded in follow-up of the recipients. Donors with small RCCs can be accepted to increase the donor pool. Collaboration in a multidisciplinary setting is fundamental to accurately evaluate donor candidate risk assessment and to improve standardized protocols for surgeons and pathologists.
Sections du résumé
BACKGROUND
BACKGROUND
We report the findings of a single Italian center in the evaluation of renal lesions in deceased donors from 2001 to 2017. In risk evaluation, we applied the current Italian guidelines, which include donors with small (< 4 cm, stage pT1a) renal carcinomas in the category of non-standard donors with a negligible risk of cancer transmission.
METHODS
METHODS
From the revision of our registries, 2,406 donors were considered in the Emilia Romagna region of Italy; organs were accepted from 1,321 individuals for a total of 3,406 organs.
RESULTS
RESULTS
The evaluation of donor safety required frozen section analysis for 51 donors, in which a renal suspicious lesion was detected by ultrasound. Thirty-two primary renal tumors were finally diagnosed: 26 identified by frozen sections and 6 in discarded kidneys. The 32 tumors included 13 clear cell renal cell carcinomas (RCCs), 6 papillary RCCs, 6 angiomyolipomas, 5 oncocytomas, 1 chromophobe RCC, and 1 papillary adenoma. No cases of tumor transmission were recorded in follow-up of the recipients.
CONCLUSION
CONCLUSIONS
Donors with small RCCs can be accepted to increase the donor pool. Collaboration in a multidisciplinary setting is fundamental to accurately evaluate donor candidate risk assessment and to improve standardized protocols for surgeons and pathologists.
Identifiants
pubmed: 32855366
pii: j.krcp.20.050
doi: 10.23876/j.krcp.20.050
pmc: PMC7770991
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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