Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice recommendations for the management of severe dermatological toxicities from checkpoint inhibitors.


Journal

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
ISSN: 1433-7339
Titre abrégé: Support Care Cancer
Pays: Germany
ID NLM: 9302957

Informations de publication

Date de publication:
Dec 2020
Historique:
received: 24 04 2020
accepted: 20 08 2020
pubmed: 29 8 2020
medline: 21 1 2021
entrez: 29 8 2020
Statut: ppublish

Résumé

Immune checkpoint inhibitors (ICIs) frequently result in cutaneous immune-related adverse events (IrAEs). Although the majority of these events are mild-to-moderate in severity, up to 5% are severe, which may lead to morbidity and dose interruption or discontinuation of ICI therapy. In addition, up to 25% of dermatologic IrAEs are corticosteroid-refractory or corticosteroid-dependent. These 2020 MASCC recommendations cover the diagnosis and management of cutaneous IrAEs with a focus on moderate-to-severe and corticosteroid-resistant events. Although the usage of immune-suppressive therapy has been advocated in this setting, there is a lack of randomized clinical trial data to provide a compelling level of evidence of its therapeutic benefit.

Identifiants

pubmed: 32856211
doi: 10.1007/s00520-020-05706-4
pii: 10.1007/s00520-020-05706-4
pmc: PMC8996262
mid: NIHMS1743129
doi:

Substances chimiques

Immune Checkpoint Inhibitors 0

Types de publication

Historical Article Journal Article Practice Guideline Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

6119-6128

Subventions

Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIAMS NIH HHS
ID : U01 AR077511
Pays : United States

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Auteurs

Jennifer Choi (J)

Division of Oncodermatology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Ronald Anderson (R)

Faculty of Health Sciences, Department of Immunology, University or Pretoria, Corner Doctor Savage Road and Bophelo Road, PO Box 667, Pretoria, 0002, South Africa.

Ada Blidner (A)

Laboratory of Immunopathology, Institute of Biology and Experimental Medicine-CONICET, Buenos Aires, Argentina.

Tim Cooksley (T)

Manchester University Foundation Trust, Manchester, UK.
The Christie, University of Manchester, Manchester, UK.

Michael Dougan (M)

Massachusetts General Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.

Ilya Glezerman (I)

Renal Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

Pamela Ginex (P)

Oncology Nursing Society, Pittsburgh, PA, USA.

Monica Girotra (M)

Endocrine Division, Department of Medicine, Weill Cornell Medical College (MG, AF), New York, NY, USA.
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

Dipti Gupta (D)

Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

Douglas Johnson (D)

Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN, USA.

Vickie R Shannon (VR)

Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Maria Suarez-Almazor (M)

Section of Rheumatology and Clinical Immunology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Bernardo L Rapoport (BL)

Faculty of Health Sciences, Department of Immunology, University or Pretoria, Corner Doctor Savage Road and Bophelo Road, PO Box 667, Pretoria, 0002, South Africa. bernardo.rapoport@up.ac.za.
The Medical Oncology Centre of Rosebank, 129 Oxford Road, Saxonwold, 2196, Johannesburg, South Africa. bernardo.rapoport@up.ac.za.

Mario E Lacouture (ME)

Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, Outpatient Center, New York, NY, USA.

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