Engineered Ferritin Nanoparticles for the Bioluminescence Tracking of Nanodrug Delivery in Cancer.
apoferritin nanoparticles
luciferase/luciferin
nanomedicine
self-immolative linkers
tumor targeting
Journal
Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
05
03
2020
revised:
16
07
2020
pubmed:
29
8
2020
medline:
4
5
2021
entrez:
29
8
2020
Statut:
ppublish
Résumé
The identification of a highly sensitive method to check the delivery of administered nanodrugs into the tumor cells is a crucial step of preclinical studies aimed to develop new nanoformulated cures, since it allows the real therapeutic potential of these devices to be forecast. In the present work, the ability of an H-ferritin (HFn) nanocage, already investigated as a powerful tool for cancer therapy thanks to its ability to actively interact with the transferrin receptor 1, to act as an efficient probe for the monitoring of nanodrug delivery to tumors is demonstrated. The final formulation is a bioluminescent nanoparticle, where the luciferin probe is conjugated on nanoparticle surface by means of a disulfide containing linker (Luc-linker@HFn) which is subjected to glutathione-induced cyclization in tumor cell cytoplasm. The prolonged imaging of luciferase+ tumor models, demonstrated by an in vitro and an in vivo approach, associated with the prolonged release of luciferin into cancer cells by disulfide bridge reduction, clearly indicates the high efficiency of Luc-linker@HFn for drug delivery to the tumor tissues.
Identifiants
pubmed: 32856404
doi: 10.1002/smll.202001450
doi:
Substances chimiques
Apoferritins
9013-31-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2001450Informations de copyright
© 2020 Wiley-VCH GmbH.
Références
M. Bellini, S. Mazzucchelli, E. Galbiati, S. Sommaruga, L. Fiandra, M. Truffi, M. A. Rizzuto, M. Colombo, P. Tortora, F. Corsi, D. Prosperi, J. Controlled Release 2014, 196, 184.
D. He, J. Marles-Wright, New Biotechnol. 2015, 32, 651.
Z. Zhen, W. Tang, C. Guo, H. Chen, X. Lin, G. Liu, B. Fei, X. Chen, B. Xu, J. Xie, ACS Nano 2013, 7, 6988.
M. Truffi, L. Fiandra, L. Sorrentino, M. Monieri, F. Corsi, S. Mazzucchelli, Pharmacol. Res. 2016, 107, 57.
K. Fan, C. Cao, Y. Pan, D. Lu, D. Yang, J. Feng, L. Song, M. Liang, X. Yan, Nat. Nanotechnol. 2012, 7, 459.
Z. Zhen, W. Tang, H. Chen, X. Lin, T. Todd, G. Wang, T. Cowger, X. Chen, J. Xie, ACS Nano 2013, 7, 4830.
M. Liang, K. Fan, M. Zhou, D. Duan, J. Zheng, D. Yang, J. Feng, X. Yan, Proc. Natl. Acad. Sci. USA 2014, 111, 14900.
L. Zhang, L. Li, A. Di Penta, U. Carmona, F. Yang, R. Schöps, M. Brandsch, J. L. Zugaza, M. Knez, Adv. Healthcare Mater. 2015, 4, 1305.
S. Mazzucchelli, M. Bellini, L. Fiandra, M. Truffi, M. A. Rizzuto, L. Sorrentino, E. Longhi, M. Nebuloni, D. Prosperi, F. Corsi, Oncotarget 2017, 8, 8383.
H. Zhou, W. Qian, F. M. Uckun, L. Wang, Y. A. Wang, H. Chen, D. Kooby, Q. Yu, M. Lipowska, C. A. Staley, H. Mao, L. Yang, ACS Nano 2015, 9, 7976.
W. Il Choi, J. H. Lee, J. Y. Kim, S. U. Heo, Y. Y. Jeong, Y. H. Kim, G. Tae, Nanomedicine. 2015, 11, 359.
T. Tagami, W. D. Foltz, M. J. Ernsting, C. M. Lee, I. F. Tannock, J. P. May, S. D. Li, Biomaterials 2011, 32, 6570.
Z. Wang, H. Gao, Y. Zhang, G. Liu, G. Niu, X. Chen, Front. Chem. Sci. Eng. 2017, 11, 633.
C. H. Contag, B. D. Ross, J. Magn. Reson. Imaging 2002, 16, 378.
T. Hirano, Curr. Top. Med. Chem. 2016, 16, 2638.
R. T. Sadikot, T. S. Blackwell, Proc. Am. Thorac. Soc. 2005, 2, 537.
A. R. Patel, E. Lim, K. P. Francis, M. Singh, Pharm. Res. 2014, 31, 3073.
Y. Yang, Q. Shao, R. Deng, C. Wang, X. Teng, K. Cheng, Z. Cheng, L. Huang, Z. Liu, X. Liu, B. Xing, Angew. Chem. 2012, 51, 3125.
P. A. Wender, E. A. Goun, L. R. Jones, T. H. Pillow, J. B. Rothbard, R. Shinde, C. H. Contag, Proc. Natl. Acad. Sci. USA 2007, 104, 10340.
L. R. Jones, E. A. Goun, R. Shinde, J. B. Rothbard, C. H. Contag, P. A. Wender, J. Am. Chem. Soc. 2006, 128, 6526.
E. Eiríksdóttir, Ü. Langel, K. Rosenthal-Aizman, Tetrahedron Lett. 2009, 50, 4731.
M. Deponte, Biochim. Biophys. Acta, Gen. Subj. 2013, 1830, 3217.
K. M. Mayle, A. M. Le, D. T. Kamei, Biochim. Biophys. Acta, Gen. Subj. 2012, 1820, 264.
L. Pandolfi, M. Bellini, R. Vanna, C. Morasso, A. Zago, S. Carcano, S. Avvakumova, J. A. Bertolini, M. A. Rizzuto, M. Colombo, D. Prosperi, Biomacromolecules 2017, 18, 3318.
M. S. Evans, J. P. Chaurette, S. T. Adams, G. R. Reddy, M. A. Paley, N. Aronin, J. A. Prescher, S. C. Miller, Nat. Methods 2014, 11, 393.
S. Mazzucchelli, M. Truffi, F. Baccarini, M. Beretta, L. Sorrentino, M. Bellini, M. A. Rizzuto, R. Ottria, A. Ravelli, P. Ciuffreda, D. Prosperi, F. Corsi, Sci. Rep. 2017, 7, 7505.