Osteoprotegerin Prevents Intracranial Aneurysm Progression by Promoting Collagen Biosynthesis and Vascular Smooth Muscle Cell Proliferation.
Animals
Case-Control Studies
Cell Proliferation
Collagen
/ biosynthesis
Disease Progression
Infusion Pumps
Infusions, Intraventricular
Intracranial Aneurysm
/ genetics
Male
Models, Animal
Muscle, Smooth, Vascular
/ metabolism
Osteoprotegerin
/ administration & dosage
Proliferating Cell Nuclear Antigen
/ metabolism
Rats
Rats, Sprague-Dawley
Signal Transduction
/ genetics
Smad2 Protein
/ metabolism
Smad3 Protein
/ metabolism
Transforming Growth Factor beta1
/ metabolism
Up-Regulation
cell proliferation
collagen
intracranial aneurysm
osteoprotegerin
transforming growth factor‐β1
vascular smooth muscle cell
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
pubmed:
29
8
2020
medline:
10
3
2021
entrez:
29
8
2020
Statut:
ppublish
Résumé
Background Decreased extracellular matrix formation and few vascular smooth muscle cells (VSMCs) in cerebral vascular walls are the main characteristics of intracranial aneurysm (IA) pathogenesis. Recently, osteoprotegerin was reported to activate collagen biosynthesis and VSMC proliferation via the TGF-β1 (transforming growth factor-β1) signaling. This study aimed to investigate whether osteoprotegerin can prevent IA progression in rats through enhanced collagen expression and VSMC proliferation. Methods and Results IAs were surgically induced in 7-week-old male Sprague-Dawley rats; at 1-week post-operation, recombinant mouse osteoprotegerin or vehicle control was continuously infused for 4 weeks into the lateral ventricle using an osmotic pump. In the osteoprotegerin-treatment group, the aneurysmal size was significantly smaller (37.5 μm versus 60.0 μm;
Identifiants
pubmed: 32856519
doi: 10.1161/JAHA.119.015731
pmc: PMC7660769
doi:
Substances chimiques
Osteoprotegerin
0
Proliferating Cell Nuclear Antigen
0
Smad2 Protein
0
Smad2 protein, rat
0
Smad3 Protein
0
Smad3 protein, rat
0
Tnfrsf11b protein, rat
0
Transforming Growth Factor beta1
0
Collagen
9007-34-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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