miR-34a is upregulated in AIP-mutated somatotropinomas and promotes octreotide resistance.
Animals
Cell Line
Cell Movement
Cell Proliferation
Drug Resistance, Neoplasm
Female
Fibroblasts
/ cytology
Gene Expression Regulation, Neoplastic
Germ-Line Mutation
Growth Hormone-Secreting Pituitary Adenoma
/ drug therapy
Humans
Intracellular Signaling Peptides and Proteins
/ genetics
Male
Mice
MicroRNAs
/ genetics
Octreotide
/ pharmacology
Pituitary Neoplasms
/ drug therapy
Up-Regulation
G protein subunit alpha i2
aryl hydrocarbon receptor-interacting protein
miR-34a
octreotide resistance
pituitary adenoma
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
15 12 2020
15 12 2020
Historique:
received:
10
12
2019
revised:
15
07
2020
accepted:
12
08
2020
pubmed:
29
8
2020
medline:
17
4
2021
entrez:
29
8
2020
Statut:
ppublish
Résumé
Pituitary adenomas (PAs) are intracranial tumors associated with significant morbidity due to hormonal dysregulation, mass effects and have a heavy treatment burden. Growth hormone (GH)-secreting PAs (somatotropinomas) cause acromegaly-gigantism. Genetic forms of somatotropinomas due to germline AIP mutations (AIPmut+) have an early onset and are aggressive and resistant to treatment with somatostatin analogs (SSAs), including octreotide. The molecular underpinnings of these clinical features remain unclear. We investigated the role of miRNA dysregulation in AIPmut+ vs AIPmut- PA samples by array analysis. miR-34a and miR-145 were highly expressed in AIPmut+ vs AIPmut- somatotropinomas. Ectopic expression of AIPmut (p.R271W) in Aip
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
MIRN145 microRNA, human
0
MIRN34 microRNA, human
0
MicroRNAs
0
aryl hydrocarbon receptor-interacting protein
0
Octreotide
RWM8CCW8GP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3523-3538Informations de copyright
© 2020 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of Union for International Cancer Control.
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