Coffee Consumption and Lung Cancer Risk: A Prospective Cohort Study in Khon Kaen Thailand.
Coffee
Lung cancer
cohort
risk factors
Journal
Asian Pacific journal of cancer prevention : APJCP
ISSN: 2476-762X
Titre abrégé: Asian Pac J Cancer Prev
Pays: Thailand
ID NLM: 101130625
Informations de publication
Date de publication:
01 Aug 2020
01 Aug 2020
Historique:
received:
18
05
2020
entrez:
29
8
2020
pubmed:
29
8
2020
medline:
4
6
2021
Statut:
epublish
Résumé
Lung cancer is a major cause of cancer death worldwide. The incidence of lung cancer in Thailand increasing, but risk factors are rarely reported. To investigate the effect of coffee consumption on lung cancer in Thai population. Between 1990 and 2001, lifestyle and demographic data were collected from 24,528 participants in the Khon Kaen Cohort Study (KKCS), who were followed through 2016, by linking to the Khon Kaen Population-based Cancer Registry. A total of 12,668 eligible participants (68.8% females, mean age 51.0 years at baseline) having complete datasets (239,488 person-years of follow up with 138 incident cases of lung cancer observed) were analyzed using a multi-variable adjusted Cox proportional hazard models. Coffee consumption was associated with reduced risk for lung cancer (adj. HR = 0.54; 95% CI: 0.35-0.84) after adjusting for age and gender. Cigarette smoking (adj. HR = 2.76; 95% CI: 1.32-5.78) and family history of cancer (adj. HR = 1.65; 95% CI: 1.10-2.48) were associated with higher risk. This study suggests coffee consumption may be a protective factor for lung cancer in among this cohort.<br />.
Sections du résumé
BACKGROUND
BACKGROUND
Lung cancer is a major cause of cancer death worldwide. The incidence of lung cancer in Thailand increasing, but risk factors are rarely reported.
OBJECTIVE
OBJECTIVE
To investigate the effect of coffee consumption on lung cancer in Thai population.
METHODS
METHODS
Between 1990 and 2001, lifestyle and demographic data were collected from 24,528 participants in the Khon Kaen Cohort Study (KKCS), who were followed through 2016, by linking to the Khon Kaen Population-based Cancer Registry. A total of 12,668 eligible participants (68.8% females, mean age 51.0 years at baseline) having complete datasets (239,488 person-years of follow up with 138 incident cases of lung cancer observed) were analyzed using a multi-variable adjusted Cox proportional hazard models.
RESULTS
RESULTS
Coffee consumption was associated with reduced risk for lung cancer (adj. HR = 0.54; 95% CI: 0.35-0.84) after adjusting for age and gender. Cigarette smoking (adj. HR = 2.76; 95% CI: 1.32-5.78) and family history of cancer (adj. HR = 1.65; 95% CI: 1.10-2.48) were associated with higher risk.
CONCLUSION
CONCLUSIONS
This study suggests coffee consumption may be a protective factor for lung cancer in among this cohort.<br />.
Identifiants
pubmed: 32856867
doi: 10.31557/APJCP.2020.21.8.2367
pmc: PMC7771955
pii:
doi:
Substances chimiques
Coffee
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2367-2371Références
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