hPSC-derived organoids: models of human development and disease.
Cell signaling
Development
Disease modeling
Human
Organoids
Stem cells
Journal
Journal of molecular medicine (Berlin, Germany)
ISSN: 1432-1440
Titre abrégé: J Mol Med (Berl)
Pays: Germany
ID NLM: 9504370
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
21
04
2020
accepted:
18
08
2020
revised:
30
06
2020
pubmed:
29
8
2020
medline:
30
11
2021
entrez:
29
8
2020
Statut:
ppublish
Résumé
Organoids derived from human pluripotent stem cells (hPSCs) have emerged as important models for investigating human-specific aspects of development and disease. Here we discuss hPSC-derived organoids through the lens of development-highlighting how stages of human development align with the development of hPSC-derived organoids in the tissue culture dish. Using hPSC-derived lung and intestinal organoids as examples, we discuss the value and application of such systems for understanding human biology, as well as strategies for enhancing organoid complexity and maturity.
Identifiants
pubmed: 32857169
doi: 10.1007/s00109-020-01969-w
pii: 10.1007/s00109-020-01969-w
pmc: PMC7914270
mid: NIHMS1624716
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
463-473Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL119215
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI116482
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK085532
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK103141
Pays : United States
Organisme : NIDCR NIH HHS
ID : T32 DE007057
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK085532
Pays : United States
Commentaires et corrections
Type : ErratumIn
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