Common and gender-specific associations with cocaine use on gray matter volume: Data from the ENIGMA addiction working group.
addiction
cocaine
gender differences
gray matter volume
hippocampus
insula
lingual gyrus
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
26
06
2020
received:
12
04
2020
accepted:
10
07
2020
pubmed:
29
8
2020
medline:
29
3
2022
entrez:
29
8
2020
Statut:
ppublish
Résumé
Gray matter volume (GMV) in frontal cortical and limbic regions is susceptible to cocaine-associated reductions in cocaine-dependent individuals (CD) and is negatively associated with duration of cocaine use. Gender differences in CD individuals have been reported clinically and in the context of neural responses to cue-induced craving and stress reactivity. The variability of GMV in select brain areas between men and women (e.g., limbic regions) underscores the importance of exploring interaction effects between gender and cocaine dependence on brain structure. Therefore, voxel-based morphometry data derived from the ENIGMA Addiction Consortium were used to investigate potential gender differences in GMV in CD individuals compared to matched controls (CTL). T1-weighted MRI scans and clinical data were pooled from seven sites yielding 420 gender- and age-matched participants: CD men (CDM, n = 140); CD women (CDW, n = 70); control men (CTLM, n = 140); and control women (CTLW, n = 70). Differences in GMV were assessed using a 2 × 2 ANCOVA, and voxelwise whole-brain linear regressions were conducted to explore relationships between GMV and duration of cocaine use. All analyses were corrected for age, total intracranial volume, and site. Diagnostic differences were predominantly found in frontal regions (CD < CTL). Interestingly, gender × diagnosis interactions in the left anterior insula and left lingual gyrus were also documented, driven by differences in women (CDW < CTLW). Further, lower right hippocampal GMV was associated with greater cocaine duration in CDM. Given the importance of the anterior insula to interoception and the hippocampus to learning contextual associations, results may point to gender-specific mechanisms in cocaine addiction.
Identifiants
pubmed: 32857473
doi: 10.1002/hbm.25141
pmc: PMC8675419
doi:
Types de publication
Journal Article
Meta-Analysis
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
543-554Subventions
Organisme : NIH HHS
ID : R01DA041528
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA041528
Pays : United States
Organisme : NIH HHS
ID : R21DA044749
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA048301
Pays : United States
Organisme : NIH HHS
ID : P50-DA016556
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIH HHS
ID : Ul1-DE024859
Pays : United States
Organisme : NIDA NIH HHS
ID : 1R21DA038381
Pays : United States
Organisme : NIDA NIH HHS
ID : K01 DA043615
Pays : United States
Organisme : NIH HHS
ID : R01-AA013892
Pays : United States
Organisme : NIDA NIH HHS
ID : P50 DA016556
Pays : United States
Organisme : NIH HHS
ID : R01DA023248
Pays : United States
Organisme : NIDA NIH HHS
ID : 1R01DA04830-01A1
Pays : United States
Organisme : NIH HHS
ID : K01DA043615
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA013892
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA047851
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA044749
Pays : United States
Organisme : NIH HHS
ID : R01MH117601
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA007135
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH117601
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA023248
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA047119
Pays : United States
Organisme : NIDA NIH HHS
ID : 1R01DA047119-01
Pays : United States
Organisme : NIH HHS
ID : R01DA047851
Pays : United States
Organisme : NIH HHS
ID : U54 EB 020403
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA038381
Pays : United States
Informations de copyright
© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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