Epigenetic control of myeloid cells behavior by Histone Deacetylase activity (HDAC) during tissue and organ regeneration in Xenopus laevis.
Epigenetics
Histone deacetylase
Myeloid cells
Tissue and organ regeneration
Xenopus laevis tail
Journal
Developmental and comparative immunology
ISSN: 1879-0089
Titre abrégé: Dev Comp Immunol
Pays: United States
ID NLM: 7708205
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
09
05
2020
revised:
18
08
2020
accepted:
18
08
2020
pubmed:
29
8
2020
medline:
10
2
2022
entrez:
29
8
2020
Statut:
ppublish
Résumé
In the present work we have focused on the Histone Deacetylase (HDAC) control of myeloid cells behavior during Xenopus tail regeneration. Here we show that myeloid differentiation is crucial to modulate the regenerative ability of Xenopus tadpoles in a HDAC activity-dependent fashion. HDAC activity inhibition during the first wave of myeloid differentiation disrupted myeloid cells dynamics in the regenerative bud as well the mRNA expression pattern of myeloid markers, such as LURP, MPOX, Spib and mmp7. We also functionally bridge the spatial and temporal dynamics of lipid droplets, the main platform of lipid mediators synthesis in myeloid cells during the inflammatory response, and the regenerative ability of Xenopus tadpoles. In addition, we showed that 15-LOX activity is necessary during tail regeneration. Taken together our results support a role for the epigenetic control of myeloid behavior during tissue and organ regeneration, which may positively impact translational approaches for regenerative medicine.
Identifiants
pubmed: 32858087
pii: S0145-305X(20)30395-5
doi: 10.1016/j.dci.2020.103840
pii:
doi:
Substances chimiques
Biomarkers
0
Histone Deacetylases
EC 3.5.1.98
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103840Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.