Toll-like receptors in Alzheimer's disease.
Alzheimer disease
Amyloid-beta
Inflammation
Microglia
Single nucleotide polymorphisms
Toll-like receptor
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 11 2020
15 11 2020
Historique:
received:
30
06
2020
revised:
04
08
2020
accepted:
15
08
2020
pubmed:
29
8
2020
medline:
15
12
2020
entrez:
29
8
2020
Statut:
ppublish
Résumé
Neuroinflammation and microglial dysfunction are key contributors to the development of Alzheimer's disease (AD). Toll-like receptors (TLRs) are transmembrane proteins primarily involved in immune responses and expressed by several immune and non-immune cells within the central nervous system. Signaling of TLRs affects the core of AD changes, including synaptic plasticity, microglial activity, tau phosphorylation, and inflammatory responses. We reviewed the activity, expression, potential applications, and genetic polymorphisms of TLRs in AD. Activation of TLRs has shown both destructive and protective effects. Several genetic polymorphisms of TLRs have been also recognized as protective or risk factors for AD. We concluded that TLRs are one of the major components of AD pathogenesis, particularly in the early stages of the disease, which can provide novel therapeutic options.
Identifiants
pubmed: 32858428
pii: S0165-5728(20)30432-X
doi: 10.1016/j.jneuroim.2020.577362
pii:
doi:
Substances chimiques
Toll-Like Receptors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
577362Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no competing interests.