Suppressing endoplasmic reticulum stress-related autophagy attenuates retinal light injury.
Acetylcysteine
/ pharmacology
Adenine
/ analogs & derivatives
Animals
Antioxidants
/ pharmacology
Autophagy
/ drug effects
Cell Line
Endoplasmic Reticulum Stress
/ drug effects
Humans
Indoles
/ pharmacology
Light
/ adverse effects
Male
Mice, Inbred C57BL
Neuroprotective Agents
/ pharmacology
Oxidative Stress
/ drug effects
Photoreceptor Cells, Vertebrate
/ drug effects
Retinal Pigment Epithelium
/ drug effects
eIF-2 Kinase
/ genetics
AMD
ER stress
PERK
autophagy
oxidative stress
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
28 08 2020
28 08 2020
Historique:
received:
11
02
2020
accepted:
30
06
2020
pubmed:
29
8
2020
medline:
23
4
2021
entrez:
29
8
2020
Statut:
ppublish
Résumé
Excessive light exposure is a principal environmental factor, which can cause damage to photoreceptors and retinal pigment epithelium (RPE) cells and may accelerate the progression of age-related macular degeneration (AMD). In this study, oxidative stress, endoplasmic reticulum (ER) stress and autophagy caused by light exposure were evaluated
Identifiants
pubmed: 32858529
doi: 10.18632/aging.103846
pii: 103846
pmc: PMC7485697
doi:
Substances chimiques
7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine
0
Antioxidants
0
Indoles
0
Neuroprotective Agents
0
3-methyladenine
5142-23-4
PERK kinase
EC 2.7.11.1
eIF-2 Kinase
EC 2.7.11.1
Adenine
JAC85A2161
Acetylcysteine
WYQ7N0BPYC
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16579-16596Références
Photochem Photobiol Sci. 2015 Sep 26;14(9):1560-77
pubmed: 26198091
Cell Cycle. 2009 Dec;8(23):3838-47
pubmed: 19887912
J Neurochem. 2017 Mar;140(6):845-861
pubmed: 28027414
Prog Retin Eye Res. 2010 Mar;29(2):113-34
pubmed: 19951742
Autophagy. 2016;12(1):1-222
pubmed: 26799652
Adv Pharmacol. 2014;70:1-36
pubmed: 24931191
Mediators Inflamm. 2015;2015:398483
pubmed: 26221063
J Biol Chem. 2002 Apr 12;277(15):13045-52
pubmed: 11821395
Biochem Biophys Res Commun. 2014 Jul 25;450(2):966-72
pubmed: 24971547
PLoS One. 2017 Jul 24;12(7):e0181667
pubmed: 28742151
Semin Cell Dev Biol. 2010 Sep;21(7):683-90
pubmed: 20223289
Br J Ophthalmol. 2013 Apr;97(4):389-94
pubmed: 23143904
Cancer Biol Ther. 2006 Jul;5(7):723-8
pubmed: 16861899
Biochim Biophys Acta. 2007 Sep;1773(9):1473-82
pubmed: 17673310
Autophagy. 2007 Sep-Oct;3(5):499-501
pubmed: 17617737
Am J Pathol. 2008 Nov;173(5):1508-17
pubmed: 18818381
Mol Psychiatry. 2017 Jun;22(6):865-873
pubmed: 27573878
Surv Ophthalmol. 2006 Sep-Oct;51(5):461-81
pubmed: 16950247
Prog Retin Eye Res. 2020 Apr 13;:100858
pubmed: 32298788
F1000Res. 2018 Apr 13;7:454
pubmed: 29744037
Autophagy. 2017 Jan 2;13(1):212-213
pubmed: 27791533
Photochem Photobiol. 1979 Apr;29(4):713-6
pubmed: 221949
Neural Regen Res. 2013 Aug 25;8(24):2275-83
pubmed: 25206537
J Biophotonics. 2018 Jul;11(7):e201700377
pubmed: 29603665
Int Rev Cell Mol Biol. 2015;317:1-66
pubmed: 26008783
Mol Cancer. 2015 May 06;14:101
pubmed: 25944097
Antioxid Redox Signal. 2007 Dec;9(12):2277-93
pubmed: 17979528
Int J Mol Sci. 2016 Mar 02;17(3):327
pubmed: 26950115
Biogerontology. 2018 Jul;19(3-4):223-235
pubmed: 29492791
Autophagy. 2007 Nov-Dec;3(6):542-5
pubmed: 17611390
Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):L624-36
pubmed: 18689604
Science. 2011 Nov 25;334(6059):1081-6
pubmed: 22116877
Exp Eye Res. 2018 Sep;174:113-120
pubmed: 29864440
Comput Struct Biotechnol J. 2013 Sep 03;6:e201303010
pubmed: 24688718
Curr Mol Med. 2015;15(8):735-45
pubmed: 26391548
J Cell Physiol. 2018 May;233(5):3867-3874
pubmed: 28777470
Antioxidants (Basel). 2019 Aug 10;8(8):
pubmed: 31405147
Oxid Med Cell Longev. 2016;2016:7420637
pubmed: 26885250
Prog Retin Eye Res. 2012 Jan;31(1):28-42
pubmed: 22085795
Retina. 2016 Apr;36(4):787-90
pubmed: 26441265
J Neurosci. 2010 Aug 11;30(32):10703-19
pubmed: 20702701
Autophagy. 2014;10(11):1989-2005
pubmed: 25484094
Int J Mol Sci. 2015 Jan 12;16(1):1644-56
pubmed: 25588217
PLoS One. 2018 Aug 9;13(8):e0201855
pubmed: 30092096
J Neurosci. 2005 Mar 2;25(9):2396-404
pubmed: 15745966
Free Radic Biol Med. 2018 Dec;129:569-581
pubmed: 30342188
Eye (Lond). 2016 Feb;30(2):255-63
pubmed: 26541085
Hum Mol Genet. 2007 Mar 15;16(6):618-29
pubmed: 17331981
Biochim Biophys Acta. 2014 Oct;1843(10):2143-9
pubmed: 24440276
Photochem Photobiol. 2005 Nov-Dec;81(6):1305-30
pubmed: 16120006
Nucleic Acids Res. 2013 Sep;41(16):7683-99
pubmed: 23804767
Cell Death Differ. 2018 Mar;25(3):486-541
pubmed: 29362479
Nature. 2010 Apr 29;464(7293):1386-9
pubmed: 20383122
Autophagy. 2015;11(7):995-1009
pubmed: 26043790