Caution With the Use of Lopinavir/Ritonavir in Severely Ill Patients for the Treatment of SARS-CoV-2: A Report of Severe Jaundice.
Aged
Antiviral Agents
/ adverse effects
Betacoronavirus
/ isolation & purification
COVID-19
Coronavirus Infections
/ complications
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Combinations
Female
Humans
Intensive Care Units
/ statistics & numerical data
Jaundice
/ chemically induced
Lopinavir
/ administration & dosage
Male
Middle Aged
Pandemics
Pneumonia, Viral
/ diagnosis
Prospective Studies
Retrospective Studies
Ritonavir
/ administration & dosage
SARS-CoV-2
Severity of Illness Index
Standard of Care
/ statistics & numerical data
COVID-19 Drug Treatment
Journal
The American journal of gastroenterology
ISSN: 1572-0241
Titre abrégé: Am J Gastroenterol
Pays: United States
ID NLM: 0421030
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
pubmed:
29
8
2020
medline:
21
10
2020
entrez:
29
8
2020
Statut:
ppublish
Résumé
We investigated the potential hepatotoxicity of lopinavir/ritonavir recently used in the treatment of Severe Acute Respiratory Syndrome Coronavirus. This is a retrospective cohort of critical patients in a teaching hospital: 12 treated with lopinavir/ritonavir and 30 in the standard-of-care group. Elevation occurred more frequently in patients treated with lopinavir/ritonavir (33% vs 6.7%). Caution is advised regarding the use of lopinavir/ritonavir in the most severe cases of Severe Acute Respiratory Syndrome Coronavirus.
Identifiants
pubmed: 32858566
doi: 10.14309/ajg.0000000000000828
pmc: PMC7473797
pii: 00000434-202010000-00028
doi:
Substances chimiques
Antiviral Agents
0
Drug Combinations
0
lopinavir-ritonavir drug combination
0
Lopinavir
2494G1JF75
Ritonavir
O3J8G9O825
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1716-1718Commentaires et corrections
Type : CommentIn
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